1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole

Base Information

• Chemical Name: 1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole
• CAS No.: 540510-48-3
• Molecular Formula: C₁₆H₂₄FN₃OSi
• Molecular Weight: 321.47

Synonyms:1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole

Chemical Property of 1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole

Chemical Property:

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Technology Process of 1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole

There total 1 articles about 1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(4-amino-3-fluorophenyl)-2-hydroxymethylimidazole (540510-47-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole (540510-48-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jm0497949

Reference yield:

1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole (540510-48-3) + 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride (754193-45-8) → N-[4-[(2-tert-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (540510-49-4)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm0497949

Reference yield:

1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole (540510-48-3) → N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (540510-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.48 g / DMAP / CH₂Cl₂ / 12 h / 20 °C

2: acetohydroxamic acid; aq. K₂CO₃ / dimethylformamide / 12 h / 20 °C

3: Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With dmap; acetylhydroxamic acid; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0497949

upstream raw materials:

1-(4-amino-3-fluorophenyl)-2-hydroxymethylimidazole

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-[4-[(2-tert-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-bromomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide

2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-azidomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide

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