2-Fluoroethyl methanesulfonate

Base Information

• Chemical Name: 2-Fluoroethyl methanesulfonate
• CAS No.: 461-31-4
• Molecular Formula: C3H7FO3S
• Molecular Weight: 142.151
• European Community (EC) Number: 858-365-4
• NSC Number: 52142
• DSSTox Substance ID: DTXSID20196717
• Nikkaji Number: J62.567A
• Wikidata: Q83069736
• ChEMBL ID: CHEMBL17071
• Mol file: 461-31-4.mol

Synonyms:2-Fluoroethyl methanesulfonate;461-31-4;Methanesulfonic acid, 2-fluoroethyl ester;Methanesulfonic acid 2-fluoroethyl ester;Fluoro(mesyloxy)ethane;2-Fluoroethylmethanesulfonate;CB 1522;2-Fluoroethyl methanesulphonate;NSC 52142;Ethanol, 2-fluoro-, methanesulfonate;BRN 1753795;C3H7FO3S;1-mesyloxy-2-fluoro ethane;WLN: WS1&O2F;CHEMBL17071;SCHEMBL897321;2-fluoroethyl methane sulfonate;(2-fluoroethyl) methanesulfonate;DTXSID20196717;C3-H7-F-O3-S;NSC52142;(2-Monofluoroethyl) methanesulfonate;NSC-52142;AKOS015852440;methanesulfonic acid,2-fluoroethyl ester;LS-90327;Methanesulfonic acid 2-fluoro-ethyl ester;Ethanol, 2-fluoro-, methanesulfonate (8CI);EN300-137803;F70746;J-521697

Chemical Property of 2-Fluoroethyl methanesulfonate

Chemical Property:

• Vapor Pressure: 0.0516mmHg at 25°C
• Boiling Point: 242.9°Cat760mmHg
• Flash Point: 100.7°C
• PSA: 51.75000
• Density: 1.281g/cm³
• LogP: 1.01290
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 142.00999342
• Heavy Atom Count: 8
• Complexity: 133

Purity/Quality:

98%min ^*data from raw suppliers

Methanesulfonicacid2-fluoroethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)OCCF

Technology Process of 2-Fluoroethyl methanesulfonate

There total 4 articles about 2-Fluoroethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-fluoroethanol (371-62-0) + methanesulfonyl chloride (124-63-0) → 2-fluoroethyl methanesulfonate (461-31-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 - 25 ℃; for 16h;

Reference yield: 44.0%

methanesulfonyl chloride (124-63-0) → 2-fluoroethyl methanesulfonate (461-31-4)

Guidance literature:

With antimonypentachloride; at 85 - 90 ℃; for 8h;

Reference yield:

2-fluoroethanol (371-62-0) + p-toluenesulfonyl chloride (98-59-9) → 2-fluoroethyl methanesulfonate (461-31-4)

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

2-fluoroethanol

methanesulfonyl chloride

p-toluenesulfonyl chloride

Downstream raw materials:

ethyl 3-{4-(2-fluoroethoxy)-3-methoxy-phenyl}propionate

N-t-butoxycarbonyl-4-(2-(2-fluoroethoxy)phenyl)piperazin-1-ylbutanamine

N-t-butoxycarbonyl-4-(3-(2-fluoroethoxy)phenyl)piperazin-1-ylbutanamine

(E)-4-[(2-fluoroethyl)methylamino]-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide