(2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

Base Information

Chemical Name:(2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane
CAS No.:947371-47-3
Molecular Formula:C₂₄H₂₉FN₂O₃
Molecular Weight:412.504
Hs Code.:

Synonyms:(2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

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Chemical Property of (2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

Chemical Property:

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Technology Process of (2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

There total 6 articles about (2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947371-34-8
tert-butyl [(1S,2S)-3-(4-hydroxyphenyl)-2-(3-cyanophenyl)-1-methylpropyl]carbamate

: 947371-47-3
(2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

Guidance literature:: With 2-fluoroethyl methanesulfonate; caesium carbonate; In DMF (N,N-dimethyl-formamide); at 65 ℃; for 1h;

Reference yield:

: 947371-34-8
tert-butyl [(1S,2S)-3-(4-hydroxyphenyl)-2-(3-cyanophenyl)-1-methylpropyl]carbamate

: 461-31-4
2-fluoroethyl methanesulfonate

: 947371-47-3
(2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 1h;
DOI:10.1021/jm070131b

Reference yield:

: 732982-66-0,789490-07-9
N-(1S,2S)-[2-(3-cyanophenyl)-3-(4-chlorophenyl)-1-methylpropyl]amine

: 947371-47-3
(2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / toluene / 0.33 h / 20 °C

2: potassium acetate; tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium / dioxane / 90 - 92 °C

3: 108 g / aq. oxone; sodium hydroxide; sodium bicarbonate / acetone; tetrahydrofuran

4: cesium carbonate / dimethylformamide / 1 h / 65 °C

With Oxone; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; sodium hydrogencarbonate; caesium carbonate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm070131b