N-Cyclohexyl-2-oxopropanamide

Base Information

• Chemical Name: N-Cyclohexyl-2-oxopropanamide
• CAS No.: 5525-85-9
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.224
• DSSTox Substance ID: DTXSID90511716
• Wikidata: Q82370647
• Mol file: 5525-85-9.mol

Synonyms:N-Cyclohexyl-2-oxopropanamide;5525-85-9;SCHEMBL4191605;DTXSID90511716

Chemical Property of N-Cyclohexyl-2-oxopropanamide

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 169.110278721
• Heavy Atom Count: 12
• Complexity: 183

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(=O)NC1CCCCC1

Technology Process of N-Cyclohexyl-2-oxopropanamide

There total 9 articles about N-Cyclohexyl-2-oxopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

cyclohexylamine (108-91-8,157973-60-9) + 1-(1H-imidazol-1-yl)propan-2-one (131394-02-0) → N-Cyclohexylbrenztraubensaeure-amid (5525-85-9)

Guidance literature:

With 1H-imidazole; [2,2]bipyridinyl; oxygen; copper diacetate; In toluene; at 80 ℃; for 5h;

DOI:10.1039/d1ob00129a

Reference yield: 61.0%

cyclohexylamine (108-91-8,157973-60-9) + 2-oxo-propionic acid (127-17-3) → N-Cyclohexylbrenztraubensaeure-amid (5525-85-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c8gc00987b

Reference yield: 50.0%

cyclohexylamine (108-91-8,157973-60-9) + pyruvoyl chloride (5704-66-5) → N-Cyclohexylbrenztraubensaeure-amid (5525-85-9)

Guidance literature:

With triethylamine; In diethyl ether; at -78 ℃;

upstream raw materials:

Cyclohexyl isocyanide

N-(1-chloroethylidene)-N-methylmethanaminium chloride

Brenztraubensaeure-N-cyclohexyl-imidchlorid

cyclohexylamine

Downstream raw materials:

N-cyclohexyl-2-oxopropanamide 2,4,6-tri-iso-propylbenzenesulphonylhydrazone

N-cyclohexyl-2-deuterioprop-2-enamide

N-cyclohexyl-3-hydroxy-3-methyl-2-methylenebutanamide

N-cyclohexyl-3-hydroxy-2-methylenepent-4-enamide