2-(4-Aminophenyl)-1,3,2-dithiarsolane

Base Information

• Chemical Name: 2-(4-Aminophenyl)-1,3,2-dithiarsolane
• CAS No.: 5577-20-8
• Molecular Formula: C8H10AsNS2
• Molecular Weight: 259.228
• DSSTox Substance ID: DTXSID201319515
• Nikkaji Number: J1.253.285G
• ChEMBL ID: CHEMBL3290760
• Mol file: 5577-20-8.mol

Synonyms:2-p-aminophenyl-1,3,2-dithiarsenolane;VTA2 compound

Chemical Property of 2-(4-Aminophenyl)-1,3,2-dithiarsolane

Chemical Property:

• PSA: 76.62000
• LogP: 2.02520
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 258.947061
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CS[As](S1)C2=CC=C(C=C2)N

Technology Process of 2-(4-Aminophenyl)-1,3,2-dithiarsolane

There total 7 articles about 2-(4-Aminophenyl)-1,3,2-dithiarsolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethane-1,2-dithiol (540-63-6) + p-aminophenyldichloroarsine. hydrochloride (5410-78-6) → 4-(1,3,2-dithiocycloarsenic-2-yl)aniline (5577-20-8)

Guidance literature:

With sodium hydrogencarbonate; In methanol; water;

DOI:10.1039/C8RA07860B

Reference yield: 81.0%

ethane-1,2-dithiol (540-63-6) + (4-aminophenyl)arsenous acid → 4-(1,3,2-dithiocycloarsenic-2-yl)aniline (5577-20-8)

Guidance literature:

for 1h; Reflux;

Reference yield: 74.0%

4-aminophenylarsenoxide (1122-90-3) + ethane-1,2-dithiol (540-63-6) → 4-(1,3,2-dithiocycloarsenic-2-yl)aniline (5577-20-8)

Guidance literature:

In ethanol; at 20 ℃; for 0.5h;

upstream raw materials:

4-aminophenylarsenoxide

ethane-1,2-dithiol

p-aminophenylarsonic acid

p-aminophenyldichloroarsine. hydrochloride

Downstream raw materials:

tert-butyl 6-(4-(1,3,2-dithiarsolan-2-yl)phenylamino)-6-oxohexylcarbamate

N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-aminohexanamide

NPE

N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide