N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide

Base Information

• Chemical Name: N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide
• CAS No.: 1334715-67-1
• Molecular Formula: C₂₆H₂₃AsBrN₃O₅S₂
• Molecular Weight: 676.443
• Mol file: 1334715-67-1.mol

Synonyms:N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide

Chemical Property of N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide

There total 7 articles about N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.3%

N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-aminohexanamide (1334715-64-8) + 4-bromo-5-nitro-1,8-naphthalene dicarboxylic acid anhydride (27742-73-0) → N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide (1334715-67-1)

Guidance literature:

In ethanol; for 0.666667h; Reflux;

DOI:10.1002/anie.201101317

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide (1334715-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

3: ethanol / 0.67 h / Reflux

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/anie.201101317

Reference yield:

p-aminophenylarsonic acid (98-50-0) → N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide (1334715-67-1)

Guidance literature:

Multi-step reaction with 5 steps

1: phenylhydrazine / methanol / 1.17 h / Reflux

2: ethanol / 0.17 h / Reflux

3: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

5: ethanol / 0.67 h / Reflux

With N-ethyl-N,N-diisopropylamine; phenylhydrazine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1002/anie.201101317

upstream raw materials:

p-aminophenylarsonic acid

tert-butyl 6-(4-(1,3,2-dithiarsolan-2-yl)phenylamino)-6-oxohexylcarbamate

N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-aminohexanamide

4-bromo-5-nitro-1,8-naphthalene dicarboxylic acid anhydride