2,5-Diphenylthiazole

Base Information

• Chemical Name: 2,5-Diphenylthiazole
• CAS No.: 3704-40-3
• Molecular Formula: C15H11NS
• Molecular Weight: 237.325
• DSSTox Substance ID: DTXSID50190541
• Nikkaji Number: J1.596.046I
• Wikidata: Q83062933
• Mol file: 3704-40-3.mol

Synonyms:2,5-Diphenylthiazole;3704-40-3;Thiazole, 2,5-diphenyl-;2,5-diphenylthiazol;SCHEMBL185735;DTXSID50190541;XCAHNWGVQJYSLY-UHFFFAOYSA-N;FT-0717790;AH-034/05416006

Chemical Property of 2,5-Diphenylthiazole

Chemical Property:

• Vapor Pressure: 1.38E-06mmHg at 25°C
• Boiling Point: 410.9°Cat760mmHg
• Flash Point: 207.2°C
• Density: 1.17g/cm³
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 237.06122053
• Heavy Atom Count: 17
• Complexity: 231

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(S2)C3=CC=CC=C3

Technology Process of 2,5-Diphenylthiazole

There total 59 articles about 2,5-Diphenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-phenylthiazole (1826-13-7) + iodobenzene (591-50-4) → 2,5-diphenyl-1,3-thiazole (3704-40-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triphenylphosphine; silver carbonate; In water; at 60 ℃; for 24h; regioselective reaction;

DOI:10.1039/c3sc52199k

Reference yield: 95.0%

2,5-diphenyl-4,5-dihydrothiazole → 2,5-diphenyl-1,3-thiazole (3704-40-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 50 ℃; for 16h; Molecular sieve;

DOI:10.1021/acs.orglett.7b00079

Reference yield: 93.0%

1,3-thiazole (288-47-1) + iodobenzene (591-50-4) → 2,5-diphenyl-1,3-thiazole (3704-40-3)

Guidance literature:

With bis(1,10-phenanthroline)palladium(II) hexafluorophosphate; caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 40h; Inert atmosphere;

DOI:10.1021/jo200067y

upstream raw materials:

N-(2-oxo-2-phenylethyl)benzamide

α-bromophenylacetaldehyde

benzamide

1,4-diphenyl-2-aza-1,3-butadiene

Downstream raw materials:

2,5-diphenyl-thiazole 3-oxide

3,4-diphenyl-isothiazole

4,5-diphenylthiazole

C₁₅H₁₀FNS

Refernces

• 1、 -. "A 2, 5 - diaryl five-membered heterocyclic aromatic preparation method". Paragraph 0016; 0017; 0018; 0019; 0020. . Retrieved 2019/05/15.
• 2、 Alom, Nur-E,Wu, Fan,Li, Wei. "One-Pot Strategy for Thiazoline Synthesis from Alkenes and Thioamides". supporting information. p. 930 - 933. Retrieved 2017/02/26.