(2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid

Base Information

Chemical Name:(2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid
CAS No.:6537-80-0
Molecular Formula:C₂₂H₁₈O₁₂
Molecular Weight:474.378
Hs Code.:29182900
DSSTox Substance ID:DTXSID90110066
Mol file:6537-80-0.mol

Synonyms:dl-Chicoric acid;(2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid;(-)-Chicoric acid;trans-Caffeoyltartaric acid;SCHEMBL964775;DTXSID90110066;AKOS030228562;FT-0645068;D78144

Suppliers and Price of (2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Chicoric acid
20mg
$ 390.00

TRC
Chicoric Acid
25mg
$ 155.00

TRC
Chicoric Acid
250mg
$ 1210.00

Sigma-Aldrich
Chicoric Acid United States Pharmacopeia (USP) Reference Standard
20mg
$ 906.00

Sigma-Aldrich
Chicoric Acid ≥95% (HPLC)
50mg
$ 477.00

Sigma-Aldrich
Chicoric Acid ≥95% (HPLC)
10mg
$ 102.00

JR MediChem
Cichoric?Acid?(NewProduct) 98%
20mg
$ 108.00

CSNpharm
CichoricAcid
10mg
$ 61.00

CSNpharm
CichoricAcid
5mg
$ 38.00

CSNpharm
CichoricAcid
1mg
$ 24.00

Total 85 raw suppliers

Chemical Property of (2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid

Chemical Property:

Vapor Pressure:5.86E-26mmHg at 25°C
Melting Point:200～208℃
Refractive Index:1.726
Boiling Point:785 °C at 760 mmHg
PKA:1.47±0.25(Predicted)
Flash Point:272.9 °C
PSA：208.12000
Density:1.641g/cm³
LogP:1.22840
Storage Temp.:?20°C
Solubility.:DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
XLogP3:2
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:11
Exact Mass:474.07982601
Heavy Atom Count:34
Complexity:740

Purity/Quality:

99%, ^*data from raw suppliers

Chicoric acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-42/43
Safety Statements: 22-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C=CC(=O)OC(C(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)C(=O)O)O)O
Isomeric SMILES:C1=CC(=C(C=C1C=CC(=O)O[C@H]([C@H](C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)C(=O)O)O)O
Uses Chicoric Acid is an effective inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. Also a class of cannabinomimetics with CB2 receptor-dependent and indep endent Chicoric Acid is an effective inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. Also a class of cannabinomimetics with CB2 receptor-dependent and independent

Technology Process of (2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid

There total 19 articles about (2R,3R)-2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 488148-82-9
dibenzyl (-)-(2R,3R)-2,3-bis{3-[2,3-bis(3,4-dibenzyloxy)phenyl]prop-2-enoyloxy}-L-tartrate

: 6537-80-0,52248-48-3,53797-30-1,70831-56-0,133520-29-3
(-)-chicoric acid

Guidance literature:: With triethylsilane; palladium diacetate; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/1522-2675(200208)85:8<2328::AID-HLCA2328>3.0.CO;2-X

Reference yield: 90.0%

: (2R,3R)-2,3-Bis-[(E)-3-(3,4-diacetoxy-phenyl)-acryloyloxy]-succinic acid

: 6537-80-0,52248-48-3,53797-30-1,70831-56-0,133520-29-3
(-)-chicoric acid

Guidance literature:: With hydrogenchloride; In acetone; for 3h; Heating;
DOI:10.1080/00397919808005946

Reference yield: 66.0%

: 488148-83-0
dibenzyl (+)-(2S,3S)-2,3-bis{3-[3,4-bis(benzyloxy)phenyl]prop-2-enoyloxy}-D-tartrate

: 6537-80-0,53797-30-1,70831-56-0,133520-29-3,52248-48-3
caftaric acid

Guidance literature:: With triethylsilane; palladium diacetate; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/1522-2675(200208)85:8<2328::AID-HLCA2328>3.0.CO;2-X