[4-(morpholin-4-yl)benzylidene]propanedinitrile

Base Information

• Chemical Name: [4-(morpholin-4-yl)benzylidene]propanedinitrile
• CAS No.: 66883-92-9
• Molecular Formula: C14H13 N3 O
• Molecular Weight: 239.277
• Mol file: 66883-92-9.mol

Synonyms:Propanedinitrile,[[4-(4-morpholinyl)phenyl]methylene]- (9CI); NSC 275408

Chemical Property of [4-(morpholin-4-yl)benzylidene]propanedinitrile

Chemical Property:

• Vapor Pressure: 1.5E-08mmHg at 25°C
• Boiling Point: 457.3°Cat760mmHg
• Flash Point: 230.4°C
• Density: 1.215g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(morpholin-4-yl)benzylidene]propanedinitrile

There total 5 articles about [4-(morpholin-4-yl)benzylidene]propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(4-morpholinyl)benzaldehyde (1204-86-0) + malononitrile (109-77-3) → <4-(1-Morpholinyl)benzylidene>malononitrile (66883-92-9)

Guidance literature:

With silica sodium carbonate nanoparticles; In acetonitrile; at 70 ℃; Sonication; Green chemistry;

DOI:10.5562/cca3261

Reference yield: 85.0%

morpholine (110-91-8,99108-56-2) + 4-fluorobenzylidenemalononitrile (2826-22-4) → <4-(1-Morpholinyl)benzylidene>malononitrile (66883-92-9)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1021/jm00130a020

Reference yield:

4-fluorobenzaldehyde (459-57-4) → <4-(1-Morpholinyl)benzylidene>malononitrile (66883-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / piperidine / ethanol / Heating

2: 85 percent / ethanol / 2 h / Heating

With piperidine; In ethanol;

DOI:10.1021/jm00130a020

upstream raw materials:

morpholine

4-fluorobenzaldehyde

malononitrile

4-fluorobenzylidenemalononitrile

Downstream raw materials:

5-amino-3-oxo-2-[4-(morpholin-4-yl)benzylidenyl]-7-[4-(morpholin-4-yl)phenyl]-2,3-dihydro-7H-thiazolo[3,2-a]pyridin-6,8-dicarbonitrile

5-amino-6,8-dicyano-1-methyl-7-[4-(4-morpholinyl)phenyl]-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium-2-thiolate

5-amino-6,8-dicyano-7-[4-(4-morpholinyl)phenyl]-1-(prop-2-en-1-yl)-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium-2-thiolate

5-amino-1-benzyl-6,8-dicyano-7-[4-(4-morpholinyl)phenyl]-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium-2-thiolate