4-Formylbenzal fluoride, alpha,alpha-Difluoro-p-tolualdehyde

Base Information

• Chemical Name: 4-Formylbenzal fluoride, alpha,alpha-Difluoro-p-tolualdehyde
• CAS No.: 55805-29-3
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.132
• Hs Code.: 2913000090
• Mol file: 55805-29-3.mol

Synonyms:4-Difluoromethylbenzaldehyde;p-Difluormethyl-benzaldehyd;

Chemical Property of 4-Formylbenzal fluoride, alpha,alpha-Difluoro-p-tolualdehyde

Chemical Property:

• Boiling Point: 113-115 °C(Press: 20 Torr)
• PSA: 17.07000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 2.43670

Purity/Quality:

99% ^*data from raw suppliers

4-(Difluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Formylbenzal fluoride, alpha,alpha-Difluoro-p-tolualdehyde

There total 15 articles about 4-Formylbenzal fluoride, alpha,alpha-Difluoro-p-tolualdehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(4-(difluoromethyl)phenyl)methanol (444915-77-9) → 4-(difluoromethyl)benzaldehyde (55805-29-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 67.0%

(1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone)2Zn(CF2H)2 + p-(iodophenyl)carboxaldehyde (15164-44-0) → 4-(difluoromethyl)benzaldehyde (55805-29-3)

Guidance literature:

With (1,1′-bis(diphenylphosphino)-ferrocene)Ni(COD); In dimethyl sulfoxide; at 25 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.6b00053

Reference yield: 66.0%

p-bromo-α,α-difluorotoluene (51776-71-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-(difluoromethyl)benzaldehyde (55805-29-3)

Guidance literature:

p-bromo-α,α-difluorotoluene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 15h;

upstream raw materials:

2,2'-p-phenylene-bis-[1,3]dithiolane

2,2'-p-phenylene-bis-[1,3]dithiane

(4-(difluoromethyl)phenyl)methanol

terephthalaldehyde,

Downstream raw materials:

5-(4-(difluoromethyl)phenyl)-4-methyloxazole

5-(4-(difluoromethyl)phenyl)-4-ethyloxazole

Refernces

• 1、 -. "AMINOAZOLE DERIVATIVE". Paragraph 0150-0151. . Retrieved 2019/02/09.
• 2、 -. "Difluoromethyl-substituted compound (by machine translation)". Paragraph 0068; 0069; 0072. . Retrieved 2019/10/17.