51776-71-7

Basic information

• Product Name: 1-BROMO-4-DIFLUOROMETHYLBENZENE
• Synonyms: 1-BROMO-4-DIFLUOROMETHYLBENZENE;BENZENE, 1-BROMO-4-(DIFLUOROMETHYL)-;4-Bromo-alpha,alpha-difluorotoluene, 1-Bromo-4-(difluoromethyl)benzene;4-Bromobenzal fluoride;4-Bromo-αα-difluorotoluene
• CAS NO: 51776-71-7
• Molecular Formula: C₇H₅BrF₂
• Molecular Weight: 207.02
• Product Categories: Aryl;Building Blocks;C7;Chemical Synthesis;Difluoromethyl;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks
• Mol File: 51776-71-7.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 100℃/53mm
• Flash Point: 87°C
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.604g/mLat 25℃
• Vapor Pressure: 0.31mmHg at 25°C
• Refractive Index: n20/D 1.514
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-BROMO-4-DIFLUOROMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-DIFLUOROMETHYLBENZENE(51776-71-7)
• EPA Substance Registry System: 1-BROMO-4-DIFLUOROMETHYLBENZENE(51776-71-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37-60
• RIDADR: 1993
• WGK Germany: 2
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 51776-71-7(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-difluoromethylbenzene is a chemical compound with the formula C7H5BrF2. It is a clear, colorless liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-BROMO-4-DIFLUOROMETHYLBENZENE is primarily used in the production of various chemicals and materials as a building block. It is also utilized as a solvent and reagent in organic synthesis. It is important to handle 1-bromo-4-difluoromethylbenzene with care, as it can be hazardous if not properly managed.

InChI:InChI=1/C7H5BrF2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,7H

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 5467-74-3 4-Bromophenylboronic acid 
• 106-37-6 1.4-dibromobenzene 
• 57477-93-7 hydrazone of p-bromobenzaldehyde 
• 139139-81-4 bis(4-bromophenyl)iodonium triflate 
• 108-86-1 bromobenzene 
• 106-38-7 para-bromotoluene 
• 109050-30-8 (4-bromophenyl)(fluoro)acetic acid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 1438388-96-5 tributyl(difluoromethyl)stannane 
• 913574-93-3 2-(4-bromophenyl)-2,2-difluoroacetic acid 
• 1004305-97-8 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester 

Downstream Products

• 5410-05-9 ((4-bromophenyl)methylene)dibenzene 
• 873373-34-3 1-(bromomethyl)-4-(difluoromethyl)benzene 
• 1382088-77-8 C₁₂H₈BrF₂N 
• 1263179-09-4 4-(difluoromethyl)benzene-1-sulfonyl chloride 

Relevant articles and documents

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.