[4-(Difluoromethyl)phenyl]methanol, 4-(Hydroxymethyl)benzal fluoride

Base Information

Chemical Name:[4-(Difluoromethyl)phenyl]methanol, 4-(Hydroxymethyl)benzal fluoride
CAS No.:444915-77-9
Molecular Formula:C₈H₈F₂O
Molecular Weight:158.148
Hs Code.:2906290090
Mol file:444915-77-9.mol

Synonyms:(4-(difluoromethyl)phenyl)methanol

Suppliers and Price of [4-(Difluoromethyl)phenyl]methanol, 4-(Hydroxymethyl)benzal fluoride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
4-(Difluoromethyl)benzyl alcohol
250 mg
$ 120.00

Matrix Scientific
[4-(Difluoromethyl)phenyl]methanol 97%
1g
$ 1253.00

Atlantic Research Chemicals
[4-(Difluoromethyl)phenyl]methanol 95%
1gm:
$ 562.00

A1 Biochem Labs
4-(Difluoromethyl)benzylalcohol 95%
5 g
$ 1200.00

Total 5 raw suppliers

Chemical Property of [4-(Difluoromethyl)phenyl]methanol, 4-(Hydroxymethyl)benzal fluoride

Chemical Property:

Boiling Point:234.5±35.0 °C(Predicted)
PKA:14.08±0.10(Predicted)
Density:1.205±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-(Difluoromethyl)benzyl alcohol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses [4-(Difluoromethyl)phenyl]methanol is used as a reactant in the preparation of difluoromethylated arenes via palladium-catalyzed difluoromethylation of arylboronic acids with bromodifluoroacetate.

Technology Process of [4-(Difluoromethyl)phenyl]methanol, 4-(Hydroxymethyl)benzal fluoride

There total 8 articles about [4-(Difluoromethyl)phenyl]methanol, 4-(Hydroxymethyl)benzal fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 444915-76-8
methyl 4-(difluoromethyl)benzoate

: 444915-77-9
(4-(difluoromethyl)phenyl)methanol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 60 ℃; for 4h;

Reference yield: 85.0%

: 75-45-6
Chlorodifluoromethane

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 444915-77-9
(4-(difluoromethyl)phenyl)methanol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; hydroquinone; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 110 ℃; for 48h; Inert atmosphere; Sealed tube;
DOI:10.1038/nchem.2746

Reference yield: 85.0%

: 444915-77-9
(4-(difluoromethyl)phenyl)methanol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; hydroquinone; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 110 ℃; for 48h; Schlenk technique; Inert atmosphere;