(2Z)-3-(3-Ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid

Base Information

• Chemical Name: (2Z)-3-(3-Ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid
• CAS No.: 87751-73-3
• Molecular Formula: C17H16O4
• Molecular Weight: 284.312
• Hs Code.: 2918990090
• Mol file: 87751-73-3.mol

Synonyms:(2Z)-3-(3-ETHOXY-4-HYDROXYPHENYL)-2-PHENYLACRYLIC ACID;(Z)-3-(3-ETHOXY-4-HYDROXY-PHENYL)-2-PHENYL-PROP-2-ENOATE;

Chemical Property of (2Z)-3-(3-Ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid

Chemical Property:

• Vapor Pressure: 6.71E-08mmHg at 25°C
• Boiling Point: 422.7 °C at 760 mmHg
• Flash Point: 152.6 °C
• PSA: 66.76000
• Density: 1.257 g/cm³
• LogP: 3.41610

Purity/Quality:

99% ^*data from raw suppliers

(2Z)-3-(3-ETHOXY-4-HYDROXYPHENYL)-2-PHENYLACRYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2Z)-3-(3-Ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid

There total 3 articles about (2Z)-3-(3-Ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-3-(3-acetoxy-4-ethoxyphenyl)-2-phenylacrylic acid → (E)-3-(3-ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid (87751-73-3)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1016/j.bmc.2019.04.020

Reference yield:

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) + sodium phenylacetate (114-70-5) → (E)-3-(3-ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid (87751-73-3)

Guidance literature:

With acetic anhydride;

DOI:10.1021/ja01208a028

Reference yield:

phenylacetic acid (103-82-2) + 4-ethoxy-3-hydroxybenzaldehyde (2539-53-9) → (E)-3-(3-ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid (87751-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 3 h / 90 °C

2: sodium hydroxide / 1,4-dioxane; water / 20 °C

With triethylamine; sodium hydroxide; In 1,4-dioxane; water;

DOI:10.1016/j.bmc.2019.04.020

upstream raw materials:

4-hydroxy-3-ethoxybenzaldehyde

sodium phenylacetate

phenylacetic acid

4-ethoxy-3-hydroxybenzaldehyde