Sodium phenylacetate

Base Information

• Chemical Name: Sodium phenylacetate
• CAS No.: 114-70-5
• Molecular Formula: C8H7NaO2
• Molecular Weight: 158.132
• Hs Code.: 2916340090
• Mol file: 114-70-5.mol

Synonyms:Aceticacid, phenyl-, Na salt (5CI);Acetic acid, phenyl-, sodium salt (8CI);Benzeneacetic acid, sodium salt (9CI);Sodium benzeneacetate;

Chemical Property of Sodium phenylacetate

Chemical Property:

• Appearance/Colour: Clear yellow to brown.
• Vapor Pressure: 0Pa at 25℃
• Melting Point: -37oC
• Boiling Point: 265.5 °C at 760 mmHg
• Flash Point: 156.2 °C
• PSA: 40.13000
• Density: 1.257g/cm3
• LogP: -0.02100
• Water Solubility.: 1000g/L at 25℃

Purity/Quality:

99.50% ^*data from raw suppliers

NAPA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium phenylacetate is pale yellow in aqueous solution. It is used as a precursor in production of penicillin G; intermediate for producing heavy metal salts which act as fungicides. Used with sodium benzoate for the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle. anesthetic (local)

Technology Process of Sodium phenylacetate

There total 9 articles about Sodium phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

Benzeneacetamide (103-81-1) → sodium phenylacetate (114-70-5)

Guidance literature:

Benzeneacetamide; With hydrogenchloride; water; Heating;

With sodium hydroxide; Reagent/catalyst;

Reference yield: 97.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + benzyl chloride (100-44-7) → benzyl methyl ether (538-86-3) + sodium phenylacetate (114-70-5)

Guidance literature:

With sodium hydroxide; dicobalt octacarbonyl; at 60 - 65 ℃; under 760.051 - 2280.15 Torr;

DOI:10.1134/S1070427207060183

Reference yield:

propyl phenylacetate (4606-15-9) → 1-Propyl acetate (109-60-4) + sodium phenylacetate (114-70-5)

Guidance literature:

upstream raw materials:

benzyl sodium

methylammonium carbonate

phenylacetic acid

Ethyl 2-phenylethanoate

Downstream raw materials:

3-(2-furyl)-2-phenylacrylic acid

(E)-2-phenyl-3-(2'-furyl)-propenoic acid

4-phenyl-1t-(2-nitro-phenyl)-pentadien-(1.3ξ)-oic acid-(5)

(E)-3-(3-ethoxy-4-hydroxyphenyl)-2-phenylacrylic acid

Refernces

• 1、 -. "Sodium phenylacetate crystal form A, and preparation method and application thereof". Paragraph 0026-0039; 0044-0047. . Retrieved 2019/07/16.
• 2、 Cui, Xiaoneng,Zhao, Jianzhang,Yang, Pei,Sun, Jifu. "Zinc(ii) tetraphenyltetrabenzoporphyrin complex as triplet photosensitizer for triplet-triplet annihilation upconversion". supporting information. p. 10221 - 10223. Retrieved 2013/10/22.