2-Ethoxy-4-hydroxy-6-methylpyrimidine

Base Information

• Chemical Name: 2-Ethoxy-4-hydroxy-6-methylpyrimidine
• CAS No.: 55996-04-8
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.169
• Hs Code.: 2933599090
• Mol file: 55996-04-8.mol

Synonyms:6-methyl-2-etoxy-4(3H)-pyrimidinone;2-Aethoxy-6-methyl-3H-pyrimidin-4-on;2-ethoxy-6-methyl-3H-pyrimidin-4-one;2-Ethoxy-6-methylpyrimidin-4(3H)-one;2-Ethoxy-4-hydroxy-6-methylpyrimidine;2-ethoxy-6-methyl-3-hydropyrimidin-4-one;

Chemical Property of 2-Ethoxy-4-hydroxy-6-methylpyrimidine

Chemical Property:

• PSA: 54.98000
• LogP: 0.47700

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxy-6-methylpyrimidin-4(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethoxy-4-hydroxy-6-methylpyrimidine

There total 4 articles about 2-Ethoxy-4-hydroxy-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-methyl-2-methoxy-4(3H)-pyrimidinone (55996-28-6) + ethanol (64-17-5) → 6-methyl-2-etoxy-4(3H)-pyrimidinone (55996-04-8)

Guidance literature:

With sodium; for 48h; Heating;

DOI:10.1016/0040-4020(84)85016-4

Reference yield:

2,4-dichloro-6-methylpyrimidine (5424-21-5) → 6-methyl-2-etoxy-4(3H)-pyrimidinone (55996-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

With acetic acid;

DOI:10.1021/ja01850a039

Reference yield:

ethyl acetoacetate (141-97-9) + O-ethylisourea (28464-55-3) → 6-methyl-2-etoxy-4(3H)-pyrimidinone (55996-04-8)

Guidance literature:

at 60 ℃;

upstream raw materials:

ethanol

ethyl acetoacetate

O-ethylisourea

6-methyl-2-methoxy-4(3H)-pyrimidinone

Downstream raw materials:

6-Methyluracil

chloroethane

4'-[(2-ethoxy-4-methyl-6-oxopyrimidin-1(6H)-yl)methyl]biphenyl-2-carbonitrile