1-Bromo-2-propanol

Base Information

• Chemical Name: 1-Bromo-2-propanol
• CAS No.: 19686-73-8
• Deprecated CAS: 19785-84-3
• Molecular Formula: C3H7 Br O
• Molecular Weight: 138.992
• Hs Code.: 29055998
• European Community (EC) Number: 243-225-1,232-943-0,612-812-8
• UN Number: 1993
• UNII: 7DGL334X4W
• DSSTox Substance ID: DTXSID8024656
• Nikkaji Number: J3.458D
• Wikidata: Q27268119
• Mol file: 19686-73-8.mol

Synonyms:1-BROMO-2-PROPANOL;1-Bromopropan-2-ol;19686-73-8;2-Propanol, 1-bromo-;Propylene bromohydrin;2-Hydroxypropyl bromide;1-Bromo-2-hydroxypropane;2-hydroxybromopropane;CCRIS 5978;2-Hydroxy-2-methylethyl bromide;1-bromo-propan-2-ol;EINECS 243-225-1;BRN 1071195;UNII-7DGL334X4W;7DGL334X4W;2-hydroxy propyl bromide;racemic 1-bromo-2-propanol;(rac)-1-bromo-propan-2-ol;SCHEMBL368283;DTXSID8024656;CHEBI:144331;LS-974;MFCD00004529;AKOS015912532;(+/-)-1-BROMO-2-PROPANOL;1-Bromo-2-propanol, analytical standard;1-BROMO-2-PROPANOL, (+/-)-;9054-89-1;B0640;CS-0063182;FT-0607465;EN300-87278;D73281;J-012726;Q27268119;1-Bromo-2-propanol, technical grade, 70%, contains MgO as stabilizer;61951-89-1

Chemical Property of 1-Bromo-2-propanol

Chemical Property:

• Appearance/Colour: colourless to brown liquid
• Vapor Pressure: 1.99mmHg at 25°C
• Refractive Index: n20/D 1.480(lit.)
• Boiling Point: 144.8°Cat760mmHg
• PKA: 13.89±0.20(Predicted)
• Flash Point: 54.4°C
• PSA: 20.23000
• Density: 1.559g/cm³
• LogP: 0.76210
• Storage Temp.: Refrigerator
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 137.96803
• Heavy Atom Count: 5
• Complexity: 22.9
• Transport DOT Label: Flammable Liquid

Purity/Quality:

98% ^*data from raw suppliers

1-Bromo-2-propanol (contains ca. 20% 2-Bromo-1-propanol)(stabilized with MgO) >79.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 10-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Halogenated Alcohols
• Canonical SMILES: CC(CBr)O

Technology Process of 1-Bromo-2-propanol

There total 24 articles about 1-Bromo-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyloxirane (75-56-9,16033-71-9) → 1-bromo-2-propanol (19686-73-8)

Guidance literature:

With dimethylbromosulphonium bromide; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2006.04.059

Reference yield: 80.0%

methyloxirane (75-56-9,16033-71-9) → 1-bromo-2-propanol (19686-73-8) + 2-bromopropanol (598-18-5)

Guidance literature:

With ammonium cerium(IV) nitrate; tetrabutylammomium bromide; In tert-butyl alcohol; for 2h; Ambient temperature;

DOI:10.1080/00397919708003362

Reference yield: 52.0%

1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 1-bromo-2-propanol (19686-73-8)

Guidance literature:

With para-dinitrobenzene; Bu₃Sn(HMPA)I; tri-n-butyl-tin hydride; In tetrahydrofuran; at 60 ℃; for 24h;

DOI:10.1016/0040-4039(95)02027-M

upstream raw materials:

propene

diethyl ether

1,2-dibromoethyl acetate

methylmagnesium bromide

Downstream raw materials:

fluoro-acetic acid-(β-bromo-isopropyl ester)

1-(methylthio)propan-2-ol

stearic acid-(2-hydroxy-propyl ester)

propylene glycol distearate

Refernces

• 1、 Soroka, Miros?aw,Goldeman, Waldemar. "Reinvestigation of the conversion of epoxides into halohydrins with elemental halogen catalysed by thiourea". . p. 4233 - 4235. Retrieved 2005.
• 2、 Wang, Zheng,Wang, Yajun,Xie, Qianjie,Fan, Zhiying,Shen, Yehua. "Aliphatic carboxylic acid as a hydrogen-bond donor for converting CO2and epoxide into cyclic carbonate under mild conditions". . p. 9403 - 9408. Retrieved 2021.
• 3、 Lambert, Tristan H.,Steiniger, Keri A.. "Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide Catalyzed Hydrosilylation of Terminal Epoxides". supporting information. p. 8013 - 8017. Retrieved 2021/10/25.
• 4、 Torabi, Parviz,Azizian, Javad,Zomorodbakhsh, Shahab. "H2TPP organocatalysis in mild and highly regioselective ring opening of epoxides to halo alcohols by means of halogen elements". experimental part. p. 5508 - 5519. Retrieved 2012/08/28.