5,7-Methanoisoquinoline, 3-(2-fluorophenyl)-5,6,7,8-tetrahydro-6,6,8-trimethyl-, (5S,7S,8R)-

Base Information

Chemical Name:5,7-Methanoisoquinoline, 3-(2-fluorophenyl)-5,6,7,8-tetrahydro-6,6,8-trimethyl-, (5S,7S,8R)-
CAS No.:561280-07-7
Molecular Formula:C19H20FN
Molecular Weight:281.373
Hs Code.:

Synonyms:

Suppliers and Price of 5,7-Methanoisoquinoline, 3-(2-fluorophenyl)-5,6,7,8-tetrahydro-6,6,8-trimethyl-, (5S,7S,8R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5,7-Methanoisoquinoline, 3-(2-fluorophenyl)-5,6,7,8-tetrahydro-6,6,8-trimethyl-, (5S,7S,8R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5,7-Methanoisoquinoline, 3-(2-fluorophenyl)-5,6,7,8-tetrahydro-6,6,8-trimethyl-, (5S,7S,8R)-

There total 5 articles about 5,7-Methanoisoquinoline, 3-(2-fluorophenyl)-5,6,7,8-tetrahydro-6,6,8-trimethyl-, (5S,7S,8R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 409319-21-7
(1S,9S)-(+)-5-(2-fluorophenyl)-10,10-dimethyl-6-azatricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-triene

: 74-88-4
methyl iodide

: 561280-07-7
(1R,8S,9S)-(+)-5-(2-fluorophenyl)-8,10,10-trimethyl-6-azatricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-triene

Guidance literature:: (1S,9S)-(+)-5-(2-fluorophenyl)-10,10-dimethyl-6-azatricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-triene; With n-butyllithium; In tetrahydrofuran; hexane; at -40 ℃;

methyl iodide; In tetrahydrofuran; at 20 ℃; Further stages.;
DOI:10.1021/jo800246g

Reference yield:

: 7785-26-4,25766-18-1
(-)-α-pinene

: 561280-07-7
(1R,8S,9S)-(+)-5-(2-fluorophenyl)-8,10,10-trimethyl-6-azatricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-triene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5,15,10,20-tetraphenylporphyrin; acetic anhydride / Inert atmosphere

2.1: ammonium acetate / acetic acid / 110 °C / Inert atmosphere

2.2: 48 h / 110 °C / Inert atmosphere

3.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With n-butyllithium; ammonium acetate; 5,15,10,20-tetraphenylporphyrin; acetic anhydride; diisopropylamine; In tetrahydrofuran; hexane; acetic acid; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;
DOI:10.1002/chem.201203817

Reference yield:

: 1-[2-(2-fluorophenyl)-2-oxoethyl]pyridinium iodide

: 561280-07-7
(1R,8S,9S)-(+)-5-(2-fluorophenyl)-8,10,10-trimethyl-6-azatricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-triene

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / acetic acid / 110 °C / Inert atmosphere

1.2: 48 h / 110 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With n-butyllithium; ammonium acetate; diisopropylamine; In tetrahydrofuran; hexane; acetic acid; 1.1: |Kroehnke Pyridine Synthesis / 1.2: |Kroehnke Pyridine Synthesis;
DOI:10.1002/chem.201203817