1-Oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid, 4-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-2-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid, 4-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-2-oxo-, 1,1-dimethylethyl ester
• CAS No.: 561313-88-0
• Molecular Formula: C30H39FN2O5
• Molecular Weight: 526.648

Synonyms:

Chemical Property of 1-Oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid, 4-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-2-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 1-Oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid, 4-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-2-oxo-, 1,1-dimethylethyl ester

There total 1 articles about 1-Oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid, 4-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-2-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-isobutoxy benzyl bromide (561313-82-4) + 4-(4-fluorobenzyl)-2-oxo-1-oxa-3,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (561313-92-6) + 4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, hydrochloride (561313-76-6) → 4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-2-oxo-1-oxa-3,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (561313-88-0)

Guidance literature:

In n-heptane; ethyl acetate;

Reference yield: 38.0%

ethyl bromide (74-96-4) + 4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-2-oxo-1-oxa-3,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (561313-88-0) + 8-(2-[1,3]Dioxolan-2-yl-ethyl)-4-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-oxa-3.8diaza-spiro[4.5]decan-2-one, hydrochloride (561313-94-8) → 4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-ethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, hydrochloride (561314-08-7)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield: 29.0%

4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-2-oxo-1-oxa-3,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (561313-88-0) + 4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-isopropyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, hydrochloride (561313-98-2) → 4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, hydrochloride

Guidance literature:

upstream raw materials:

4-isobutoxy benzyl bromide

4-(4-fluorobenzyl)-2-oxo-1-oxa-3,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, hydrochloride

Downstream raw materials:

8-(2-[1,3]Dioxolan-2-yl-ethyl)-4-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-oxa-3.8diaza-spiro[4.5]decan-2-one, hydrochloride

4-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-ethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, hydrochloride

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