Ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate
CAS No.:56517-53-4
Molecular Formula:C12H15NO4
Molecular Weight:237.255
Hs Code.:

Synonyms:3-carboethoxy-4-hydroxy-5,6,7,8-tetrahydrocarbostyril;3-carboethoxy-4-hydroxy-5,6,7,8-tetrahydro-2(1H)-quinolone;ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate;4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid ethyl ester;

Suppliers and Price of Ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate 97%
1g
$ 573.00

Chemenu
Ethyl4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate 97%
1g
$ 541.00

Total 4 raw suppliers

Chemical Property of Ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate

Chemical Property:

PSA：79.39000
LogP:1.13600

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate

There total 14 articles about Ethyl 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1128-00-3
ethyl 2-aminocyclohex-1-ene-1-carboxylate

: 105-53-3
diethyl malonate

: 56517-53-4
4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydro-3(1H)-quinolinecarboxylic acid ethl ester

Guidance literature:: With sodium ethanolate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; at 120 - 150 ℃; for 19h;
DOI:10.1016/j.bmc.2012.07.034

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 56517-53-4
4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydro-3(1H)-quinolinecarboxylic acid ethl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N, ethyl chloroformate / H₂O; acetone / 0.5 h / 0 °C

2: NaN₃ / H₂O / 1 h / 0 °C

3: toluene / 0.67 h / 100 °C

4: 1.) NaH / 1.) toluene, 0 deg C, 2.) from 0 deg C to RT, 90 min

5: diphenyl ether / 0.08 h / 235 °C

With sodium azide; chloroformic acid ethyl ester; sodium hydride; triethylamine; In diphenylether; water; acetone; toluene;
DOI:10.1021/jo00358a046