2,4-Dichloro-5,6,7,8-tetrahydroquinoline

Base Information

• Chemical Name: 2,4-Dichloro-5,6,7,8-tetrahydroquinoline
• CAS No.: 858279-01-3
• Molecular Formula: C9H9Cl2N
• Molecular Weight: 202.083
• Hs Code.: 2933499090
• Mol file: 858279-01-3.mol

Synonyms:2,4-Dichloro-5,6,7,8-tetrahydroquinoline

Chemical Property of 2,4-Dichloro-5,6,7,8-tetrahydroquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 3.26720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,4-dichloro-5,6,7,8-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-5,6,7,8-tetrahydroquinoline

There total 4 articles about 2,4-Dichloro-5,6,7,8-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-tetrahydroquinoline-2,4-diol (56517-59-0) → 2,4-dichloro-5,6,7,8-tetrahydroquinoline (858279-01-3)

Guidance literature:

With trichlorophosphate; at 180 ℃;

DOI:10.1002/hlca.6602801233

Reference yield:

2,4-dihydroxy-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester (56517-53-4) → 2,4-dichloro-5,6,7,8-tetrahydroquinoline (858279-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; hydrochloric acid

2: phosphoryl chloride / 180 °C

With hydrogenchloride; water; trichlorophosphate;

DOI:10.1002/hlca.6602801233

Reference yield:

ethyl 2-aminocyclohex-1-ene-1-carboxylate (1128-00-3) → 2,4-dichloro-5,6,7,8-tetrahydroquinoline (858279-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethylate; ethanol

2: water; hydrochloric acid

3: phosphoryl chloride / 180 °C

With hydrogenchloride; ethanol; water; sodium ethanolate; trichlorophosphate;

DOI:10.1002/hlca.6602801233

upstream raw materials:

5,6,7,8-tetrahydroquinoline-2,4-diol

2,4-dihydroxy-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

ethyl 2-aminocyclohex-1-ene-1-carboxylate

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

trans-decahydroquinoline

quinoline

5,6,7,8-tetrahydroquinoline