2,4-Diaminobutyric acid

Base Information

• Chemical Name: 2,4-Diaminobutyric acid
• CAS No.: 305-62-4
• Molecular Formula: C₄H₁₀N₂O₂
• Molecular Weight: 118.136
• Hs Code.: 2922499990
• European Community (EC) Number: 206-166-2
• UNII: 92V7KM11ZK
• DSSTox Substance ID: DTXSID80862749
• Nikkaji Number: J79.591G
• Wikidata: Q27895750
• Metabolomics Workbench ID: 1876
• ChEMBL ID: CHEMBL307931
• Mol file: 305-62-4.mol

Synonyms:2,4-diaminobutyric acid;2,4-diaminobutyric acid dihydrochloride, (+-)-isomer;2,4-diaminobutyric acid dihydrochloride, (S)-isomer;2,4-diaminobutyric acid monohydrochloride, (+-)-isomer;2,4-diaminobutyric acid monohydrochloride, (S)-isomer;2,4-diaminobutyric acid, (+)-isomer;2,4-diaminobutyric acid, (+-)-isomer;2,4-diaminobutyric acid, (R)-isomer;2,4-diaminobutyric acid, (S)-isomer;L-2,4-diaminobutyric acid

Chemical Property of 2,4-Diaminobutyric acid

Chemical Property:

• Melting Point: 144 °C
• Refractive Index: 1.4386 (estimate)
• Boiling Point: 220.67°C (rough estimate)
• PKA: 1.85, 8.24, 10.44(at 25℃)
• Flash Point: 147.927oC
• PSA: 89.34000
• Density: 1.2188 (rough estimate)
• LogP: 0.14770
• Storage Temp.: 2-8°C
• XLogP3: -4.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 118.074227566
• Heavy Atom Count: 8
• Complexity: 84.1

Purity/Quality:

98%min ^*data from raw suppliers

2,4-DIAMINO-BUTYRICACID 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CN)C(C(=O)O)N
• Uses: 2,4-Diaminobutanoic Acid is a useful starting material.

Technology Process of 2,4-Diaminobutyric acid

There total 25 articles about 2,4-Diaminobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

<2,6-bis(1,1-dimethylethyl)-4-methoxyphenyl>-2,4-bis(acetamido)butanoat (113719-16-7) → 2,4-diaminobutanoic acid (305-62-4,1758-80-1,2577-63-1,26908-94-1,60484-56-2)

Guidance literature:

With formic acid; dihydrogen peroxide; for 0.0833333h; Ambient temperature; then 30 min. 60 deg.C;

DOI:10.1002/hlca.19870700607

Reference yield:

benzoylglycyl-Nγ-(pivaloyloxy)glutamine N-methylamide (85701-37-7) → 2,4-diaminobutanoic acid (305-62-4,1758-80-1,2577-63-1,26908-94-1,60484-56-2) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + glycine (56-40-6,18875-39-3,25718-94-9) + methylamine (74-89-5)

Guidance literature:

With Lossen degradation; Product distribution;

DOI:10.1021/jo00160a015

Reference yield:

C17H24N4O5*H(1+) → 2,4-diaminobutanoic acid (305-62-4,1758-80-1,2577-63-1,26908-94-1,60484-56-2) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6)

Guidance literature:

With Lossen degradation; at 50 ℃; Product distribution; pH8.5, var. α-glutamyl peptides, degradation yield;

DOI:10.1021/jo00160a015

upstream raw materials:

propane-1,1,3-tricarboxylic acid

3-amino-pyrrolidin-2-one

Pht-D/L-Dab(Pht)-OH

3-thioxo-tetrahydro-pyrrolo[1,2-c]imidazole-1,5-dione

Downstream raw materials:

2,4-bis-benzoylamino-butyric acid

3-amino-pyrrolidin-2-one

2-Amino-4-benzyloxycarbonylamino-butyric acid

glycine

Refernces

• 1、 -. "Process for producing alpha 2,3/ alpha 2,8-sialyltransferase and sialic acid-containing complex sugar". . . Retrieved 2008/06/13.
• 2、 -. "Gene recombinant antibody and antibody fragment thereof". . . Retrieved 2008/06/13.