Methanesulfonic acid, trifluoro-, 1,2-dihydro-6-methyl-2-[(4-methylphenyl)sulfonyl]-4-isoquinolinyl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 1,2-dihydro-6-methyl-2-[(4-methylphenyl)sulfonyl]-4-isoquinolinyl ester
CAS No.:566883-87-2
Molecular Formula:C18H16F3NO5S2
Molecular Weight:447.456
Hs Code.:

Synonyms:

Suppliers and Price of Methanesulfonic acid, trifluoro-, 1,2-dihydro-6-methyl-2-[(4-methylphenyl)sulfonyl]-4-isoquinolinyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid, trifluoro-, 1,2-dihydro-6-methyl-2-[(4-methylphenyl)sulfonyl]-4-isoquinolinyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 1,2-dihydro-6-methyl-2-[(4-methylphenyl)sulfonyl]-4-isoquinolinyl ester

There total 5 articles about Methanesulfonic acid, trifluoro-, 1,2-dihydro-6-methyl-2-[(4-methylphenyl)sulfonyl]-4-isoquinolinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2645-02-5
methyl tosylglycinate

: 566883-87-2
N-(p-toluenesulfonyl)-6-methyl-4-(trifluoromethylsulfonyloxy)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 76 percent / naI; K₂CO₃ / acetone / 6 h / Heating

2.1: 85 percent / 10 percent NaOH / 20 °C

3.1: SOCl₂

4.1: 41 g / AlCl₃ / CH₂Cl₂ / 4 h / -78 - -11 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 °C

5.2: 77 percent / tetrahydrofuran / -78 - 20 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; potassium carbonate; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/S0968-0896(02)00561-8

Reference yield:

: 104-82-5
4-Methylbenzyl chloride

: 566883-87-2
N-(p-toluenesulfonyl)-6-methyl-4-(trifluoromethylsulfonyloxy)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 76 percent / naI; K₂CO₃ / acetone / 6 h / Heating

2.1: 85 percent / 10 percent NaOH / 20 °C

3.1: SOCl₂

4.1: 41 g / AlCl₃ / CH₂Cl₂ / 4 h / -78 - -11 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 °C

5.2: 77 percent / tetrahydrofuran / -78 - 20 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; potassium carbonate; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/S0968-0896(02)00561-8

Reference yield:

: 566883-83-8
N-(p-methylbenzyl)-N-(p-toluenesulfonyl)glycine

: 566883-87-2
N-(p-toluenesulfonyl)-6-methyl-4-(trifluoromethylsulfonyloxy)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂

2.1: 41 g / AlCl₃ / CH₂Cl₂ / 4 h / -78 - -11 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 77 percent / tetrahydrofuran / -78 - 20 °C

With aluminium trichloride; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(02)00561-8