4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

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Chemical Name:4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline
CAS No.:566883-89-4
Molecular Formula:C₂₈H₃₁NO₆S
Molecular Weight:509.623
Hs Code.:

Synonyms:4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

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Chemical Property of 4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

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Technology Process of 4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

There total 7 articles about 4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 220956-32-1
3,4-dimethoxy-2-(methoxymethoxy)methylphenylboronic acid

: 566883-87-2
N-(p-toluenesulfonyl)-6-methyl-4-(trifluoromethylsulfonyloxy)-1,2-dihydroisoquinoline

: 566883-89-4
4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

Guidance literature:: With potassium hydroxide; potassium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 90 ℃; for 1h;
DOI:10.1016/S0968-0896(02)00561-8

Reference yield:

: 2645-02-5
methyl tosylglycinate

: 566883-89-4
4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 76 percent / naI; K₂CO₃ / acetone / 6 h / Heating

2.1: 85 percent / 10 percent NaOH / 20 °C

3.1: SOCl₂

4.1: 41 g / AlCl₃ / CH₂Cl₂ / 4 h / -78 - -11 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 °C

5.2: 77 percent / tetrahydrofuran / -78 - 20 °C

6.1: 90 percent / KBr; KOH / Pd(PPh₃)4 / toluene / 1 h / 90 °C

With potassium hydroxide; sodium hydroxide; aluminium trichloride; thionyl chloride; potassium carbonate; sodium iodide; potassium bromide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetone; toluene; 6.1: Suzuki cross-coupling;
DOI:10.1016/S0968-0896(02)00561-8

Reference yield:

: 104-82-5
4-Methylbenzyl chloride

: 566883-89-4
4-(3,4-dimethoxy-2-methoxymethoxymethylphenyl)-6-methyl-N-(p-toluenesulfonyl)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 76 percent / naI; K₂CO₃ / acetone / 6 h / Heating

2.1: 85 percent / 10 percent NaOH / 20 °C

3.1: SOCl₂

4.1: 41 g / AlCl₃ / CH₂Cl₂ / 4 h / -78 - -11 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 °C

5.2: 77 percent / tetrahydrofuran / -78 - 20 °C

6.1: 90 percent / KBr; KOH / Pd(PPh₃)4 / toluene / 1 h / 90 °C

With potassium hydroxide; sodium hydroxide; aluminium trichloride; thionyl chloride; potassium carbonate; sodium iodide; potassium bromide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetone; toluene; 6.1: Suzuki cross-coupling;
DOI:10.1016/S0968-0896(02)00561-8