1-NAPHTHALENECARBONYL CHLORIDE,4-FLUORO-

Base Information

• Chemical Name: 1-NAPHTHALENECARBONYL CHLORIDE,4-FLUORO-
• CAS No.: 56886-72-7
• Molecular Formula: C11H6ClFO
• Molecular Weight: 208.61600
• Hs Code.: 2916399090
• Mol file: 56886-72-7.mol

Synonyms:4-fluoro-1-naphthoyl chloride;1-NAPHTHALENECARBONYL CHLORIDE,4-FLUORO-;4-fluoronaphthalenecarbonyl chloride;4-fluoro-1-napthoyl chloride;4-fluoronaphthoyl chloride;

Chemical Property of 1-NAPHTHALENECARBONYL CHLORIDE,4-FLUORO-

Chemical Property:

• PSA: 17.07000
• LogP: 3.35790

Purity/Quality:

99%, ^*data from raw suppliers

4-Fluoro-1-naphthalenecarbonyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-NAPHTHALENECARBONYL CHLORIDE,4-FLUORO-

There total 2 articles about 1-NAPHTHALENECARBONYL CHLORIDE,4-FLUORO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-1-naphthoic acid (573-03-5) → 4-fluoro-1-naphthoic acid chloride (56886-72-7)

Guidance literature:

With thionyl chloride; at 70 ℃; for 2h;

DOI:10.1021/jm0502743

Reference yield:

→ 4-fluoro-1-naphthoic acid chloride (56886-72-7)

Guidance literature:

Reference yield: 10.0%

1-pentyl-1H-indole (59529-21-4) + 4-fluoro-1-naphthoic acid chloride (56886-72-7) → (4-fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (1364933-59-4)

Guidance literature:

1-pentyl-1H-indole; With dimethylaluminum chloride; In hexane; dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

4-fluoro-1-naphthoic acid chloride; In hexane; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2012.01.038

upstream raw materials:

4-fluoro-1-naphthoic acid

Downstream raw materials:

4-fluoro-naphthalene-1-carboxylic acid phenyl ester

(4-fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

C₂₇H₂₉N₃O₂

methyl 4-(2-cyanophenoxy)-1-naphthoate