3-Amino-N-(2-diethylaminoethyl)-1,8-naphthalimide

Base Information

• Chemical Name: 3-Amino-N-(2-diethylaminoethyl)-1,8-naphthalimide
• CAS No.: 69408-82-8
• Molecular Formula: C18H21N3O2
• Molecular Weight: 311.3782
• Mol file: 69408-82-8.mol

Synonyms:5-amino-2-[2-(diethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione,5-amino-2-[2-(diethylamino)ethyl];3-Amino-N-(2-diethylaminoethyl)-1,8-naphthalimide;5-Amino-2-(2-(diethylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione;

Chemical Property of 3-Amino-N-(2-diethylaminoethyl)-1,8-naphthalimide

Chemical Property:

• Vapor Pressure: 9.06E-11mmHg at 25°C
• Boiling Point: 516.4°Cat760mmHg
• Flash Point: 266.1°C
• PSA: 68.33000
• Density: 1.246g/cm³
• LogP: 2.45790
• Storage Temp.: 2-8°C
• Solubility.: DMSO: >20mg/mL

Purity/Quality:

99% ^*data from raw suppliers

NSC308848 ≥98% (HPLC), powder ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 53-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-Amino-N-(2-diethylaminoethyl)-1,8-naphthalimide

There total 7 articles about 3-Amino-N-(2-diethylaminoethyl)-1,8-naphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-amino-naphthalene-1,8-dicarboxylic acid-anhydride (23204-38-8) + N,N-diethylethylenediamine (100-36-7) → 5-amino-2-(2-diethylaminoethyl)-1H-benzisoquinoline-1,3(2H)-dione (69408-82-8)

Guidance literature:

In ethanol; for 2h; Ambient temperature;

Reference yield: 79.5%

5-nitro-2-(2-diethylaminoethyl)-1H-benzisoquinoline-1,3(2H)-dione (54824-18-9) → 5-amino-2-(2-diethylaminoethyl)-1H-benzisoquinoline-1,3(2H)-dione (69408-82-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

3-nitro-1,8-naphthalic anhydride (3027-38-1) → 5-amino-2-(2-diethylaminoethyl)-1H-benzisoquinoline-1,3(2H)-dione (69408-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.2 percent / ethanol / 3 h / Ambient temperature

2: 79.5 percent / H₂ / Pd/C 10percent / ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

5-nitro-2-(2-diethylaminoethyl)-1H-benzisoquinoline-1,3(2H)-dione

3-amino-naphthalene-1,8-dicarboxylic acid-anhydride

N,N-diethylethylenediamine

3-nitro-1,8-naphthalic anhydride

Refernces

• 1、 da Settimo,Primofiore,Livi,Tonetti,Tellini,Bianchini. "Synthesis and local anesthetic activity of some N-β- diethylaminoethylnaphtalimides". . p. 105 - 115. Retrieved 2007/10/02.