1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone
• CAS No.: 10420-97-0
• Molecular Formula: C14H13 N O2
• Molecular Weight: 227.263
• Mol file: 10420-97-0.mol

Synonyms:Acetophenone,4'-methoxy-2-(2-pyridyl)- (7CI,8CI); 1-(4-Methoxyphenyl)-2-(2-pyridyl)ethanone;4-Methoxyphenyl-2-picolylketone; NSC 42682

Chemical Property of 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone

Chemical Property:

• Vapor Pressure: 2.61E-06mmHg at 25°C
• Boiling Point: 390.6°Cat760mmHg
• Flash Point: 190.1°C
• Density: 1.142g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone

There total 11 articles about 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

α-picoline (109-06-8) + 4,N-dimethoxy-N-methylbenzamide (52898-49-4) → 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone (10420-97-0)

Guidance literature:

α-picoline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

4,N-dimethoxy-N-methylbenzamide; In tetrahydrofuran; hexane; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c3ob40578h

Reference yield: 66.0%

(4-methoxyphenyl)(2-methylaziridin-1-yl)methanone (303162-29-0) + α-picoline (109-06-8) → 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone (10420-97-0)

Guidance literature:

α-picoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -10 ℃; for 0.333333h;

(4-methoxyphenyl)(2-methylaziridin-1-yl)methanone; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1248/cpb.53.410

Reference yield:

α-picoline (109-06-8) + 4-methoxybenzonitrile (874-90-8) → 1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone (10420-97-0)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -75 deg C, 10 min, 2.) THF, hexane, a) -75 deg C, 1 h, b) RT, 2 h;

upstream raw materials:

α-picoline

4-methoxybenzonitrile

(2-picolyl)trimethylsilane

(Z)-1-(4-methoxy-phenyl)-2-[2]pyridyl-vinyl alcohol

Downstream raw materials:

1-(4-hydroxy-phenyl)-2-[2]pyridyl-ethanone

2-bromo-1-(4-methoxyphenyl)-2-(pyridin-2-yl)ethanone

1-(4-methoxyphenyl)-2-[N-(3-methoxyphenyl)-N-ethylamino]-2-(pyridin-2-yl)ethanone

3-(4-methoxyphenyl)-2-(pyridin-2-yl)-1H-indole