4,N-Dimethoxy-N-methylbenzamide

Base Information

• Chemical Name: 4,N-Dimethoxy-N-methylbenzamide
• CAS No.: 52898-49-4
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2924299090
• Mol file: 52898-49-4.mol

Synonyms:4,N-Dimethoxy-N-methylbenzamide

Chemical Property of 4,N-Dimethoxy-N-methylbenzamide

Chemical Property:

• Vapor Pressure: 6.1E-05mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 345.6 °C at 760 mmHg
• Flash Point: 162.8 °C
• PSA: 38.77000
• Density: 1.114 g/cm³
• LogP: 1.32860
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

N,4-Dimethoxy-N-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,N-Dimethoxy-N-methylbenzamide

There total 37 articles about 4,N-Dimethoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 4-methoxybenzoic acid (100-09-4) → 4,N-dimethoxy-N-methylbenzamide (52898-49-4)

Guidance literature:

4-methoxybenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Further stages.;

DOI:10.1016/j.bmc.2007.08.039

Reference yield: 99.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 4-methoxy-benzoyl chloride (100-07-2) → 4,N-dimethoxy-N-methylbenzamide (52898-49-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.200907163

Reference yield: 98.0%

4-methoxybenzoic acid (100-09-4) + N,0-dimethylhydroxylamine (1117-97-1) → 4,N-dimethoxy-N-methylbenzamide (52898-49-4)

Guidance literature:

4-methoxybenzoic acid; N,0-dimethylhydroxylamine; In toluene; at 0 ℃; for 0.166667h;

With phosphorus trichloride; In toluene; at 20 - 60 ℃; for 0.5h;

DOI:10.1055/s-0033-1340317

upstream raw materials:

N-methyl-N-(4-methoxybenzoyl)hydroxylamine

methyl p-methoxybenzenesulfonate

4-methoxybenzoic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

p-Methoxyvalerophenon

2-(4-methoxybenzoyl)thiophene

3-(2-(4-methoxybenzoyl)phenyl)-4-trimethylsilylsydnone

1-(4-methoxyphenyl)prop-2-en-1-one

Refernces

• 1、 Carminati, Daniela M.,Decaens, Jonathan,Couve-Bonnaire, Samuel,Jubault, Philippe,Fasan, Rudi. "Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes". supporting information. p. 7072 - 7076. Retrieved 2021/02/27.
• 2、 Yang, Yang,Liu, Jian,Kamounah, Fadhil S.,Ciancaleoni, Gianluca,Lee, Ji-Woong. "A CO2-Catalyzed Transamidation Reaction". . p. 16867 - 16881. Retrieved 2021/11/18.