15alpha-Hydroxyestradiol

Base Information Edit

Chemical Name:15alpha-Hydroxyestradiol
CAS No.:570-30-9
Molecular Formula:C₁₈H₂₄O₃
Molecular Weight:288.387
Hs Code.:
DSSTox Substance ID:DTXSID00972490
Nikkaji Number:J131.394K
Wikipedia:15%CE%B1-Hydroxyestradiol
Wikidata:Q27159758
Mol file:570-30-9.mol

Synonyms:15 alpha-hydroxyestradiol;15 alpha-hydroxyestradiol, (17alpha)-isomer

Suppliers and Price of 15alpha-Hydroxyestradiol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,3,5(10)-ESTRATRIEN-3,15ALPHA,17BETA-TRIOL 95.00%
5MG
$ 500.76

Total 3 raw suppliers

Chemical Property of 15alpha-Hydroxyestradiol Edit

Chemical Property:

Vapor Pressure:1.54E-10mmHg at 25°C
Boiling Point:493.1°C at 760 mmHg
Flash Point:233.7°C
PSA：60.69000
Density:1.255g/cm³
LogP:2.58000
XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:288.17254462
Heavy Atom Count:21
Complexity:411

Purity/Quality:

95% ^*data from raw suppliers

1,3,5(10)-ESTRATRIEN-3,15ALPHA,17BETA-TRIOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC3C(C1C(CC2O)O)CCC4=C3C=CC(=C4)O
Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H](C[C@@H]2O)O)CCC4=C3C=CC(=C4)O

Technology Process of 15alpha-Hydroxyestradiol

There total 11 articles about 15alpha-Hydroxyestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.6%

: 50-28-2
estradiol

: 570-30-9
1,3,5-estratriene-3,15α,17β-triol

: 2208-13-1
3,15α-dihydroxy-1,3,5(10)-estratrien-17-one

: 1,3,5-estratriene-3,6α,15α-triol-17-one

: 1229-24-9
6α-hydroxyestradiol

Guidance literature:: With potassium dihydrogenphosphate; D-glucose; water; In acetone; at 30 ℃; for 120h; pH=4.5; Microbiological reaction;
DOI:10.1080/10242422.2016.1247816

Reference yield:

: 59169-10-7
17-oxoestra-1,3,5⁽¹⁰⁾,15-tetraen-3-yl acetate

: 570-30-9
1,3,5-estratriene-3,15α,17β-triol

Guidance literature:: Multi-step reaction with 5 steps

1: TsOH

2: NaBH₄ / ethanol

3: imidazole / dimethylformamide

4: (i) BF₃-Et₂O, LiAlH₄, (ii) aq. H₂O₂, NaOH, THF

5: aq. HCl / acetone

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.23.3141