Carbamic acid, [(5S)-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-6-[[4-(hydroxymethyl) phenyl]amino]-6-oxohexyl]-, 2-propenyl ester

Base Information

• Chemical Name: Carbamic acid, [(5S)-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-6-[[4-(hydroxymethyl) phenyl]amino]-6-oxohexyl]-, 2-propenyl ester
• CAS No.: 573698-75-6
• Molecular Formula: C32H35N3O6
• Molecular Weight: 557.646
• Mol file: 573698-75-6.mol

Synonyms:

Chemical Property of Carbamic acid, [(5S)-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-6-[[4-(hydroxymethyl) phenyl]amino]-6-oxohexyl]-, 2-propenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(5S)-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-6-[[4-(hydroxymethyl) phenyl]amino]-6-oxohexyl]-, 2-propenyl ester

There total 1 articles about Carbamic acid, [(5S)-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-6-[[4-(hydroxymethyl) phenyl]amino]-6-oxohexyl]-, 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-aminobenzenemethanol (623-04-1) + (S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (146982-27-6) → (9H-fluoren-9-yl)methyl allyl (6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexane-1,5-diyl)-(S)-dicarbamate (573698-75-6)

Guidance literature:

With 2,6-dimethylpyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.0c02043

Reference yield:

(9H-fluoren-9-yl)methyl allyl (6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexane-1,5-diyl)-(S)-dicarbamate (573698-75-6) + C20H13ClFN7O2 → C52H48ClFN10O8

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 40 ℃;

DOI:10.1021/acs.jmedchem.0c02043

Reference yield:

(9H-fluoren-9-yl)methyl allyl (6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexane-1,5-diyl)-(S)-dicarbamate (573698-75-6) → (S)-4-(6-(((allyloxy)carbonyl)amino)-2-aminohexanamido)benzyl ((2-(4-(3-chloro-4-fluorophenyl)-5-(3-cyanoimidazo[1,2-b]pyridazin-6-yl)-1H-imidazole-1-yl)ethoxy)methyl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / N,N-dimethyl-formamide / 40 °C

2: piperidine / tetrahydrofuran / 1 h / 20 °C

With piperidine; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c02043

upstream raw materials:

4-aminobenzenemethanol

(S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid