L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-formyl-O-methyl-, methyl ester

Base Information

• Chemical Name: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-formyl-O-methyl-, methyl ester
• CAS No.: 574735-09-4
• Molecular Formula: C17H23NO6
• Molecular Weight: 337.36800
• Mol file: 574735-09-4.mol

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-(3-formyl-4-methoxy-phenyl)-propionic acid methyl ester;

Chemical Property of L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-formyl-O-methyl-, methyl ester

Chemical Property:

• Boiling Point: 489.3±45.0 °C(Predicted)
• PSA: 90.93000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 2.50740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-formyl-O-methyl-, methyl ester

There total 1 articles about L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-formyl-O-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(tert-butoxycarbonylamino)-3-(3-formyl-4-hydroxyphenyl)propanoic acid (186689-03-2) + methyl iodide (74-88-4) → 2-tert-butoxycarbonylamino-3-(3-formyl-4-methoxy-phenyl)-propionic acid methyl ester (574735-09-4)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃; for 16h;

DOI:10.1016/j.tetlet.2004.03.112

Reference yield: 100.0%

2-tert-butoxycarbonylamino-3-(3-formyl-4-methoxy-phenyl)-propionic acid methyl ester (574735-09-4) → N-(tert-butyloxycarbonyl)-3-(3-formyl-4-methoxyphenyl)-L-alanine (133641-14-2)

Guidance literature:

With lithium hydroxide; water; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2004.03.112

Reference yield: 95.0%

2-tert-butoxycarbonylamino-3-(3-formyl-4-methoxy-phenyl)-propionic acid methyl ester (574735-09-4) → 2-amino-3-(3-formyl-4-methoxy-phenyl)-propionic acid methyl ester

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(03)00487-3

upstream raw materials:

2-(tert-butoxycarbonylamino)-3-(3-formyl-4-hydroxyphenyl)propanoic acid

methyl iodide

Downstream raw materials:

3-(3-hydroxy-4-methoxyphenyl)-L-alanine

N-(tert-butyloxycarbonyl)-3-(3-formyl-4-methoxyphenyl)-L-alanine