Chemical Property of Flosequinan
Chemical Property:
- Vapor Pressure:2.29E-07mmHg at 25°C
- Melting Point:226-228°
- Boiling Point:423.1°C at 760 mmHg
- Flash Point:209.7°C
- PSA：58.28000
- Density:1.44g/cm3
- LogP:2.28070
- Storage Temp.:2-8°C
- XLogP3:1.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:1
- Exact Mass:239.04162790
- Heavy Atom Count:16
- Complexity:369
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Flosequinan 95+% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN1C=C(C(=O)C2=C1C=C(C=C2)F)S(=O)C
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Description
Flosequinan is a new mixed arteriolar and venous vasodilator useful for the treatment
of patients with congestive heart failure with or without ACE inhibitors, but especially
in those patients who are intolerant to ACE inhibitors. It does not cause reflex
stimulation of the renin-angiotensin or sympathetic nervous system. How flosequinan
achieves its direct vasodilating effect is not clear, it is thought to interfere with protein
kinase C and the production of inositol triphosphate. Flosequinan is well absorbed
orally, and with the relatively long half-life of its sulfone metabolite it is suitable for
once a day administration.
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Therapeutic Function
Antihypertensive, Vasodilator
