flosequinoxan

Base Information

• Chemical Name: flosequinoxan
• CAS No.: 76568-68-8
• Molecular Formula: C₁₁H₁₀FNO₃S
• Molecular Weight: 255.27
• Mol file: 76568-68-8.mol

Synonyms:BTS 53554;Flosequinan sulfone; Flosequinoxan

Chemical Property of flosequinoxan

Chemical Property:

• Vapor Pressure: 6E-08mmHg at 25°C
• Boiling Point: 440.2°C at 760 mmHg
• Flash Point: 220°C
• PSA: 64.52000
• Density: 1.46g/cm³
• LogP: 2.16190

Purity/Quality:

98.5% ^*data from raw suppliers

BTS-53554 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of flosequinoxan

There total 16 articles about flosequinoxan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

7-fluoro-3-methylsulfonyl-4-quinolone (154639-78-8) + methyl iodide (74-88-4) → flosequinoxan (76568-68-8)

Guidance literature:

With potassium carbonate; 5-fluoro-3-methylsulfonyl-4-quinolone; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield: 64.0%

flosequinan (76568-02-0) → flosequinoxan (76568-68-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 72h; Ambient temperature;

Reference yield:

methyl 3-(3-fluoro-N-methylanilino)-2-methylsulfonylacrylate → flosequinoxan (76568-68-8) + 5-fluoro-1-methyl-3-methylsulfonyl-4-quinolone

Guidance literature:

With PPA; In diethyl ether; at 95 ℃; for 4.5h; Yield given. Yields of byproduct given;

upstream raw materials:

flosequinan

7-fluoro-3-methylsulfonyl-4-quinolone

methyl iodide

(-)-Flosequinan

Refernces

• 1、 Birch, Alan M.,Davies, Roy V.,Maclean, Lachlan,Robinson, Keith. "Syntheses of Flosequinan: A Novel 4-Quinolone shown to be useful in Congestive Heart Failure". . p. 387 - 392. Retrieved 2007/10/02.
• 2、 -. "Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments". . . Retrieved 2008/06/13.