2-Chloro-N-(4-fluorophenyl)nicotinamide

Base Information

• Chemical Name: 2-Chloro-N-(4-fluorophenyl)nicotinamide
• CAS No.: 57841-99-3
• Molecular Formula: C12H8ClFN2O
• Molecular Weight: 250.65600
• Mol file: 57841-99-3.mol

Synonyms:2-chloro-N-(4-fluoro-phenyl)-nicotinamide;N-(4-fluorophenyl)-2-chloro-3-pyridinecarboxamide;2-chloro-N-(4-fluorophenyl)nicotinamide;

Chemical Property of 2-Chloro-N-(4-fluorophenyl)nicotinamide

Chemical Property:

• Melting Point: 92.84 - 93.84 °C
• PSA: 41.99000
• LogP: 3.19940

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(4-fluorophenyl)nicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-(4-fluorophenyl)nicotinamide

There total 2 articles about 2-Chloro-N-(4-fluorophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Chloronicotinoyl chloride (49609-84-9) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-2-chloro-3-pyridinecarboxamide (57841-99-3)

Guidance literature:

4-fluoroaniline; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

2-Chloronicotinoyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1039/c6ob02279k

Reference yield:

→ N-(4-fluorophenyl)-2-chloro-3-pyridinecarboxamide (57841-99-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 3.0%

N-(4-fluorophenyl)-2-chloro-3-pyridinecarboxamide (57841-99-3) + 3-hydroxytrifluoroacetophenone sodium salt → N-(4-fluorophenyl)-2-(3-trifluoroacetylphenoxy)-3-pyridinecarboxamide

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

2-Chloronicotinoyl chloride

4-fluoroaniline

Downstream raw materials:

1-(4-fluorophenyl)-3-(3-trifluoromethylphenyl)-2,3-dihydropyrido<2,3-d>-pyrimidin-4(1H)-one

1-(4-fluorophenyl)-3-(3-trifluoromethylphenyl)pyrido<2,3-d>pyrimidine-2(1H),4(3H)-dione

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