Uridine, 2'-O-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]ethyl]-3-[(phenylmethoxy) methyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-

Base Information

Chemical Name:Uridine, 2'-O-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]ethyl]-3-[(phenylmethoxy) methyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-
CAS No.:581060-79-9
Molecular Formula:C46H60N2O11Si2
Molecular Weight:873.16
Hs Code.:

Uridine,
2'-O-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]ethyl]-3-[(phenylmethoxy)
methyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-

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Chemical Property of Uridine, 2'-O-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]ethyl]-3-[(phenylmethoxy) methyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-

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Technology Process of Uridine, 2'-O-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]ethyl]-3-[(phenylmethoxy) methyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-

There total 8 articles about Uridine, 2'-O-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]ethyl]-3-[(phenylmethoxy) methyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 3-Benzyloxymethyl-1-[(2R,3R,3aR,9aR)-3-(2-hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidine-2,4-dione

: 581060-79-9
Carbonic acid 2-[(2R,3R,3aR,9aR)-2-(3-benzyloxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1039/b302855k

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 581060-79-9
Carbonic acid 2-[(2R,3R,3aR,9aR)-2-(3-benzyloxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / imidazole / pyridine / 7 h / 20 °C

2: 72 percent / NaH / dimethylformamide / 2 h / -5 °C

3: 86 percent / H₂ / 20 percent Pd/C / tetrahydrofuran; methanol / 20 °C

4: 76 percent / NaBH₄ / methanol; 2-methyl-propan-2-ol / 20 °C

5: 82 percent / DBU / dimethylformamide / 20 °C

6: 86 percent / pyridine / 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/b302855k

Reference yield:

: 186839-90-7
3-[(benzyloxy)methyl]-1-(β-D-ribofuranosyl)uracil

: 581060-79-9
Carbonic acid 2-[(2R,3R,3aR,9aR)-2-(3-benzyloxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / imidazole / pyridine / 7 h / 20 °C

2: 72 percent / NaH / dimethylformamide / 2 h / -5 °C

3: 86 percent / H₂ / 20 percent Pd/C / tetrahydrofuran; methanol / 20 °C

4: 76 percent / NaBH₄ / methanol; 2-methyl-propan-2-ol / 20 °C

5: 82 percent / DBU / dimethylformamide / 20 °C

6: 86 percent / pyridine / 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/b302855k