Technology Process of 1H-Isoindole-1,3(2H)-dione,
2-[[8-[(4-methoxyphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]dec-7-yl]meth
yl]-
There total 5 articles about 1H-Isoindole-1,3(2H)-dione,
2-[[8-[(4-methoxyphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]dec-7-yl]meth
yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; pyridinium p-toluenesulfonate;
In
toluene;
at 140 ℃;
for 18h;
DOI:10.1081/SCC-120018941
- Guidance literature:
-
Multi-step reaction with 4 steps
1: molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
2: aluminum chloride / CH2Cl2 / 18 h / -78 - 20 °C
3: 12.8 g / HCl / H2O; CH2Cl2 / 2 h
4: 75 percent / pyridinum p-toluenesulfonate; molecular sieves 4 Angstroem / toluene / 18 h / 140 °C
With
hydrogenchloride; aluminium trichloride; 4 A molecular sieve; pyridinium p-toluenesulfonate;
In
dichloromethane; water; toluene;
2: hetero Diels-Alder reaction;
DOI:10.1081/SCC-120018941
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / HCl / H2O; tetrahydrofuran / 18 h / 80 °C
2: molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
3: aluminum chloride / CH2Cl2 / 18 h / -78 - 20 °C
4: 12.8 g / HCl / H2O; CH2Cl2 / 2 h
5: 75 percent / pyridinum p-toluenesulfonate; molecular sieves 4 Angstroem / toluene / 18 h / 140 °C
With
hydrogenchloride; aluminium trichloride; 4 A molecular sieve; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; water; toluene;
3: hetero Diels-Alder reaction;
DOI:10.1081/SCC-120018941
