L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-, 2-(trimethylsilyl)ethyl ester

Base Information

Chemical Name:L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-, 2-(trimethylsilyl)ethyl ester
CAS No.:582308-06-3
Molecular Formula:C44H50N2O9Si
Molecular Weight:778.975
Hs Code.:

L-Phenylalanine,
4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl]
amino]-N-[(2-propenyloxy)carbonyl]-, 2-(trimethylsilyl)ethyl ester

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Chemical Property of L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-, 2-(trimethylsilyl)ethyl ester

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Technology Process of L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-, 2-(trimethylsilyl)ethyl ester

There total 5 articles about L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-, 2-(trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39061-59-1
t-butoxalyl chloride

: 908093-98-1
diazodiphenylmethane

: 582308-05-2
2-{4-[2-(S)-allyloxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)ethyl]phenylamino}-benzoic acid

: 582308-06-3
2-({4-[2-(S)-allyloxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)-ethyl]-phenyl}-tert-butoxyoxalylamino)-benzoic acid benzhydryl ester

Guidance literature:: t-butoxalyl chloride; 2-{4-[2-(S)-allyloxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)ethyl]phenylamino}-benzoic acid; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 15h;

diazodiphenylmethane; In acetone; at 20 ℃; for 1h;
DOI:10.1021/jm034088d

Reference yield:

: 1488-42-2,109545-72-4
Diphenyliodonium-2-carboxylate

: 582308-06-3
2-({4-[2-(S)-allyloxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)-ethyl]-phenyl}-tert-butoxyoxalylamino)-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 6.97 g / Cu(OAc)2 / dimethylformamide / 2 h / 100 °C

2.1: 6.1 g / HCl / dioxane / 1 h

3.1: 6.55 g / aq. NaHCO₃ / ethyl acetate / 1 h / 20 °C

4.1: NEt₃ / CH₂Cl₂ / 15 h / 0 - 20 °C

4.2: 5.8 g / acetone / 1 h / 20 °C

With hydrogenchloride; copper diacetate; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm034088d

Reference yield:

: 174833-40-0
N-α-tert-butyloxycarbonyl-β-(p-aminophenyl)-L-alanine 2-(trimethylsilyl)ethyl ester

: 582308-06-3
2-({4-[2-(S)-allyloxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)-ethyl]-phenyl}-tert-butoxyoxalylamino)-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 6.97 g / Cu(OAc)2 / dimethylformamide / 2 h / 100 °C

2.1: 6.1 g / HCl / dioxane / 1 h

3.1: 6.55 g / aq. NaHCO₃ / ethyl acetate / 1 h / 20 °C

4.1: NEt₃ / CH₂Cl₂ / 15 h / 0 - 20 °C

4.2: 5.8 g / acetone / 1 h / 20 °C

With hydrogenchloride; copper diacetate; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm034088d