methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Base Information

Chemical Name:methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate
CAS No.:436864-58-3
Molecular Formula:C₅₁H₅₃N₃O₁₂
Molecular Weight:899.995
Hs Code.:

methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Synonyms:methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

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Chemical Property of methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

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Technology Process of methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

There total 10 articles about methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 436864-53-8
methyl 2-(4-aminobutoxy)-6-hydroxybenzoate

: 436864-57-2
2-{[4-(2-(S)-allyloxycarbonylamino-2-carboxyethyl)-phenyl]-tert-butoxyoxalylamino}-benzoic acid benzhydryl ester

: 436864-58-3
methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide;

Reference yield: 68.0%

: methyl 2-(4-aminobutoxy)-6-hydroxybenzoate hydrochloride salt

: 436864-57-2
2-{[4-(2-(S)-allyloxycarbonylamino-2-carboxyethyl)-phenyl]-tert-butoxyoxalylamino}-benzoic acid benzhydryl ester

: 436864-58-3
methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm034088d

Reference yield:

: 2150-45-0
methyl 2,6-dihydroxybenzoate

: 436864-58-3
methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 °C

2: 97 percent / HCl / dioxane / 4 h / 20 °C

3: 68 percent / 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium BF₄; triethylamine; HOBT / dimethylformamide / 2 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1021/jm034088d