Acotiamide

Base Information

Chemical Name:Acotiamide
CAS No.:185106-16-5
Molecular Formula:C₂₁H₃₀N₄O₅S
Molecular Weight:450.559
Hs Code.:
UNII:D42OWK5383
DSSTox Substance ID:DTXSID40870163
Nikkaji Number:J1.360.929B
Wikipedia:Acotiamide
Wikidata:Q4674598
NCI Thesaurus Code:C65214
Pharos Ligand ID:PB8913D71P36
Metabolomics Workbench ID:70586
ChEMBL ID:CHEMBL2107723
Mol file:185106-16-5.mol

Synonyms:acotiamide;acotiamide hydrochloride;N-(2-(diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxamide;N-(N',N'-diisopropylaminoethyl)-(2-(2-hydroxy-4,5-dimethoxybenzoylamino)-1,3-thiazole-4-yl)carboxyamide;YM 443;YM-443;YM443 cpd;Z 338;Z-338

Suppliers and Price of Acotiamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Acotiamide >98%
1 g
$ 800.00

DC Chemicals
Acotiamide >98%
250 mg
$ 400.00

DC Chemicals
Acotiamide >98%
100 mg
$ 200.00

CSNpharm
Acotiamide
50mg
$ 424.00

CSNpharm
Acotiamide
100mg
$ 721.00

Crysdot
Acotiamide 97%
100mg
$ 594.00

Chemenu
N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide 97%
100mg
$ 561.00

Total 60 raw suppliers

Chemical Property of Acotiamide

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:7.38±0.50(Predicted)
Flash Point:°C
PSA：148.24000
Density:1.246g/cm³
LogP:3.92560
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:450.19369124
Heavy Atom Count:31
Complexity:586

Purity/Quality:

99%, ^*data from raw suppliers

Acotiamide >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C
Recent ClinicalTrials:Helicobacter Pylori Eradication in Functional Dyspepsia
Recent EU Clinical Trials:The effect of acotiamide on gastric motility and satiation in healthy volunteers
Recent NIPH Clinical Trials:A Phase III Trial of Z-338 in Paediatric Patients with Functional Dyspepsia

Technology Process of Acotiamide

There total 15 articles about Acotiamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid ethyl ester

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 185106-16-5
Acotiamide

Guidance literature:: at 120 ℃; for 3h; Inert atmosphere;

Reference yield: 83.0%

: ethyl 2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate acetate

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 185106-16-5
Acotiamide

Guidance literature:: With dicyclohexyl-carbodiimide; In neat (no solvent); at 20 - 120 ℃; for 1h; Solvent; Temperature; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.5b00256