Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate

Base Information

• Chemical Name: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
• CAS No.: 877997-99-4
• Molecular Formula: C14H14N2O6S
• Molecular Weight: 338.341
• Mol file: 877997-99-4.mol

Synonyms:Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;

Chemical Property of Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate

Chemical Property:

• PSA: 135.22000
• LogP: 1.97780
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-?(2-?Hydroxy-?4,?5-?dimethoxybenzamido)?thiazole-?4-?carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-?(2-?Hydroxy-?4,?5-?dimethoxybenzamido)?thiazole-?4-?carboxylate is an Acotiamide (A190260) impurity. Acotiamide is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction.

Technology Process of Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate

There total 13 articles about Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

methyl 2-amino-1,3-thiazole-4-carboxylate (118452-04-3) + 2-hydroxy-4,5-dimethoxybenzoic acid (5722-93-0) → 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester (877997-99-4)

Guidance literature:

With 4-methyl-morpholine; 2,4-diphenoxy-6-chloro-s-triazine; In tetrahydrofuran; at 20 ℃; for 3.33333h; Reagent/catalyst; Concentration; Solvent; Cooling with ice;

Reference yield: 80.0%

methyl 2-amino-1,3-thiazole-4-carboxylate (118452-04-3) + 2-hydroxy-4,5-dimethoxybenzoic acid 4-nitrophenyl ester → 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester (877997-99-4)

Guidance literature:

In methanol; 5,5-dimethyl-1,3-cyclohexadiene; argon;

Reference yield: 55.0%

2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester (877997-98-3) → 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester (877997-99-4)

Guidance literature:

In methanol; 5,5-dimethyl-1,3-cyclohexadiene; argon;

upstream raw materials:

methyl 2-amino-1,3-thiazole-4-carboxylate

CH₄O*C₁₄H₁₄N₂O₆S

2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester

2-hydroxy-4,5-dimethoxybenzoic acid

Downstream raw materials:

2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride

N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide hydrochloride

Acotiamide