Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate

Base Information

Chemical Name:Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate
CAS No.:185105-98-0
Molecular Formula:C16H18N2O6S
Molecular Weight:366.395
Hs Code.:
UNII:P443K6KGF5
Mol file:185105-98-0.mol

Synonyms:185105-98-0;Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate;Acotiamide INT;Ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate;2-[N-(2,4,5-trimethoxybenzoyl)amino]-4-(ethoxycarbonyl)-1,3-thiazole;4-Thiazolecarboxylic acid, 2-[(2,4,5-trimethoxybenzoyl)amino]-, ethyl ester;P443K6KGF5;SCHEMBL6313414;BWDNVLPYCMAUGL-UHFFFAOYSA-N;MFCD17549707;2-[(2,4,5-trimethoxybenzoyl)amino]-4-Thiazolecarboxylic acid ethyl ester;AC-36644;BS-51340;E85302;A921104;Ethyl2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate;Ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-4-thiazolecarboxylate

Suppliers and Price of Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate 97%
10g
$ 250.00

Crysdot
Ethyl2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate 97%
5g
$ 150.00

Crysdot
Ethyl2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate 97%
1g
$ 50.00

Alichem
Ethyl2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate
10g
$ 400.00

Total 31 raw suppliers

Chemical Property of Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate

Chemical Property:

PKA:7.26±0.50(Predicted)
PSA：124.22000
Density:1.320±0.06 g/cm3(Predicted)
LogP:2.67090
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:366.08855747
Heavy Atom Count:25
Complexity:466

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2OC)OC)OC
Uses Ethyl 2-?(2,?4,?5-?Trimethoxybenzamido)?thiazole-?4-?carboxylate is an impurity of Acotiamide (A190260), an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

Technology Process of Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate

There total 7 articles about Ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 5398-36-7
2-aminothiazole-4-carboxylate

: C₁₇H₁₅NO₄S₂

: 185105-98-0
ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate

Guidance literature:: With potassium carbonate; In toluene; for 4h; Inert atmosphere; Reflux;

Reference yield: 90.0%

: 5398-36-7
2-aminothiazole-4-carboxylate

: 42833-66-9
2,4,5-trimethoxybenzoyl chloride

: 185105-98-0
ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate

Guidance literature:: 2-aminothiazole-4-carboxylate; 2,4,5-trimethoxybenzoyl chloride; In 1,2-dichloro-ethane; for 6h; Reflux;

With sodium hydroxide; In water; at 0 - 8 ℃; for 6h; pH=7.5;

Reference yield: 68.0%

: 5398-36-7
2-aminothiazole-4-carboxylate

: 490-64-2
asaronic acid

: 185105-98-0
ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate

Guidance literature:: With benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane; at 0 - 35 ℃; for 2.5h; Temperature; Reagent/catalyst; Solvent;