DESMETHYL TRIMEBUTINE HCL

Base Information

• Chemical Name: DESMETHYL TRIMEBUTINE HCL
• CAS No.: 84333-59-5
• Molecular Formula: C₂₁H₂₇NO₅
• Molecular Weight: 373.449
• Mol file: 84333-59-5.mol

Synonyms:JO 1069;N-Demethyltrimebutine; N-Monodesmethyltrimebutine

Chemical Property of DESMETHYL TRIMEBUTINE HCL

Chemical Property:

• Vapor Pressure: 6.52E-09mmHg at 25°C
• Boiling Point: 467.4°C at 760 mmHg
• Flash Point: 236.5°C
• PSA: 66.02000
• Density: 1.112g/cm³
• LogP: 4.58700

Purity/Quality:

99% ^*data from raw suppliers

N-DesMethylTrimebutineHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The main bioactive metabolite of Trimebutine

Technology Process of DESMETHYL TRIMEBUTINE HCL

There total 8 articles about DESMETHYL TRIMEBUTINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) + 2-methylamino-2-phenylbutanol (78483-47-3) → Nortrimebutine (84333-59-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -30 ℃; for 1h;

Reference yield:

ethyl 2-amino-2-phenylbutanoate (6480-87-1) → Nortrimebutine (84333-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / Ac₂O / 15 h / 20 °C

2: 97.9 percent / LiAlH₄ / tetrahydrofuran / 8 h / Heating

3: 85.1 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - -30 °C

With lithium aluminium tetrahydride; n-butyllithium; acetic anhydride; In tetrahydrofuran; hexane; 1: Formylation / 2: Reduction / 3: Esterification;

Reference yield:

phenylglycine ethyl ester hydrochloride (72651-17-3) → Nortrimebutine (84333-59-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 93 percent / MgSO₄; Et₃N / CH₂Cl₂ / 17 h / 20 °C

2: 85 percent / NaH; CuCl₂ / tetrahydrofuran / 18 h / 20 °C

3: 99 percent / HCl; Et₂O; H₂O / 24 h / 20 °C

4: 95 percent / Et₃N / tetrahydrofuran / 0.33 h

5: 99 percent / Ac₂O / 15 h / 20 °C

6: 97.9 percent / LiAlH₄ / tetrahydrofuran / 8 h / Heating

7: 85.1 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - -30 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; diethyl ether; water; acetic anhydride; sodium hydride; magnesium sulfate; triethylamine; copper dichloride; In tetrahydrofuran; hexane; dichloromethane; 1: Condensation / 2: Alkylation / 3: Hydrolysis / 4: Dehydrochlorination / 5: Formylation / 6: Reduction / 7: Esterification;

upstream raw materials:

3,4,5-Trimethoxybenzoyl chloride

2-methylamino-2-phenylbutanol

ethyl 2-amino-2-phenylbutanoate

phenylglycine ethyl ester hydrochloride

Refernces