72651-17-3

Basic information

• Product Name: D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE
• Synonyms: D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE
• CAS NO: 72651-17-3
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.67666
• Mol File: 72651-17-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE(72651-17-3)
• EPA Substance Registry System: D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE(72651-17-3)

Safety Data

• Hazardous Substances Data: 72651-17-3(Hazardous Substances Data)

Usage

General Description

D/L-Alpha-phenylglycineethylester hydrochloride is a chemical compound that is a racemic mixture of D-Alpha-phenylglycineethylester and L-Alpha-phenylglycineethylester, which are both enantiomers of each other. D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE is commonly used in organic synthesis as a chiral building block for the production of various pharmaceuticals and agrochemicals. It is also used in the production of peptides and other complex organic molecules. Additionally, it can act as a catalyst in certain chemical reactions. The hydrochloride salt form of this compound is often chosen for its increased solubility and stability in various solvents.

Upstream product

• 64-17-5 ethanol 
• 2835-06-5 phenylglycin 
• 81477-96-5 ethyl α-<(diphenylmethylene)amino>-(+/-)-benzeneacetate 

Downstream Products

• 131786-03-3 ethyl N-4-trifluorobenzylidenephenylglycinate 
• 77290-51-8 ethyl α-<<(4-chlorophenyl)methylene>amino>-DL-benzeneacetate 
• 70018-63-2 (2-Chloro-6-nitro-benzylamino)-phenyl-acetic acid ethyl ester 
• 77290-60-9 (4-Chloro-benzoylamino)-phenyl-acetic acid ethyl ester 
• 77290-62-1 (4-Methoxy-benzoylamino)-phenyl-acetic acid ethyl ester 
• 77290-59-6 (4-nitro-benzoylamino)-phenyl-acetic acid ethyl ester 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 142035-33-4 ethyl N-(phenylmethylene)glycinate 
• 1427287-73-7 C₂₆H₃₅N₆O₁₁P 
• 1211517-53-1 ethyl 1-(2-ethoxy-2-oxo-1-phenylethyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1442645-97-7 C₂₂H₁₇F₄NO₅ 
• 55240-54-5 5-hydroxy-6-phenylpyridine-3-carboxylic acid 
• 28687-87-8 5-ethoxy-2,4-diphenyloxazole 

Relevant articles and documents

Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure

With the increase of fungal infection and drug resistance, it is becoming an urgent task to discover the highly effective antifungal drugs. In the study, we selected the key ergosterol bio-synthetic enzymes (Squalene epoxidase, SE; 14 α-demethylase, CYP51) as dual-target receptors to guide the construction of novel antifungal compounds, which could achieve the purpose of improving drug efficacy and reducing drug-resistance. Three different series of amide naphthyl compounds were generated through the method of skeleton growth, and their corresponding target products were synthesized. Most of compounds displayed the obvious biological activity against different Candida spp. and Aspergillus fumigatus. Among of them, target compounds 14a-2 and 20b-2 not only possessed the excellent broad-spectrum anti-fungal activity (MIC50, 0.125–2 μg/mL), but also maintained the anti-drug-resistant fungal activity (MIC50, 1–4 μg/mL). Preliminary mechanism study revealed the compounds (14a-2, 20b-2) could block the bio-synthetic pathway of ergosterol by inhibiting the dual-target (SE/CYP51) activity, and this finally caused the cleavage and death of fungal cells. In addition, we also discovered that compounds 14a-2 and 20b-2 with low toxic and side effects could exert the excellent therapeutic effect in mice model of fungal infection, which was worthy for further in-depth study.

Synthesis of methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate

The first synthesis of the methylamino-2-phenyl-2-butyl-3,4,5- trimethoxybenzoate (desmethyltrimebutine) I is described. This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969. It was used for pharmacokinetic and bioequivalence studies.

SELECTIVE MONOPHENYLATION OF AN ACTIVE METHYLENE COMPOUND

-