6480-87-1Relevant academic research and scientific papers
Tandem N, N-Dialkylation Reaction of N-Trimethylsilyl α-Iminoesters Utilizing an Umpolung Reaction and Characteristics of the Silyl Substituent: Synthesis of Pyrrolidine, Piperidine, and Iminodiacetate
Mizota, Isao,Tadano, Yurie,Nakamura, Yusuke,Haramiishi, Tomoki,Hotta, Miyuki,Shimizu, Makoto
, p. 2663 - 2667 (2019/04/30)
Umpolung reactions of N-trimethylsilyl α-iminoester with organometallics gave directly N-alkylaminoesters in high yields without the need for removing a protecting group at the nitrogen atom. Efficient syntheses of pyrrolidines, piperidines, and iminodiacetate derivatives were also developed via tandem N,N- or N,C-dialkylation reactions utilizing characteristics of the silyl substituent. Furthermore, under the influence of silica gel, the addition of an enolate to the imino nitrogen proceeded to give an iminodiacetate derivative.
Synthesis of methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate
Martin, Arnaud,Figadere, Bruno,Saivin, Sylvie,Houin, Georges,Chomard, Jean Marie,Cahiez, Gerard
, p. 544 - 549 (2007/10/03)
The first synthesis of the methylamino-2-phenyl-2-butyl-3,4,5- trimethoxybenzoate (desmethyltrimebutine) I is described. This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969. It was used for pharmacokinetic and bioequivalence studies.
Substituted 2, 4-imidazolidinedione compounds as pharmaceutical active ingredients
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, (2008/06/13)
A substituted 2,4-imidazolidinedione compound corresponding to the formula I STR1 a process for production thereof and the use of these compounds in a pharmaceutical preparation are described. Substituents R1, R2, R3 and R4 have the same meaning as defined in the specification.
