BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE

Base Information

• Chemical Name: BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE
• CAS No.: 58609-13-5
• Molecular Formula: C22H20O3
• Molecular Weight: 332.399
• Mol file: 58609-13-5.mol

Synonyms:benzyl 4-benzyloxyphenylacetate;benzyl-4-benzyloxy phenylacetate;4-benzyloxyphenylacetic acid benzyl ester;Benzyl 2-(4-(Benzyloxy)phenyl)acetate;Benzyl 2-[4-(benzyloxy)phenyl]acetate;

Chemical Property of BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE

Chemical Property:

• PSA: 35.53000
• LogP: 4.55150

Purity/Quality:

Benzyl2-(4-(Benzyloxy)phenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzyl 2-(4-(Benzyloxy)phenyl)acetate is a reactant used in the synthesis of a benzyl-protected analog of the phenylpropanoid glycoside arenarioside.

Technology Process of BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE

There total 7 articles about BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

4-hydroxyphenylacetate (156-38-7) + benzyl bromide (100-39-0) → 4-(benzyloxy)phenylacetic acid benzyl ester (58609-13-5)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Heating;

DOI:10.1016/j.carres.2006.08.006

Reference yield: 90.1%

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) + benzyl alcohol (100-51-6,185532-71-2) → 4-(benzyloxy)phenylacetic acid benzyl ester (58609-13-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.molstruc.2021.130680

Reference yield: 88.0%

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) + benzyl bromide (100-39-0) → 4-(benzyloxy)phenylacetic acid benzyl ester (58609-13-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(98)00882-5

upstream raw materials:

4-hydroxyphenylacetate

benzyl chloride

benzyl bromide

2-[4-(benzyloxy)benzyl]acetic acid

Downstream raw materials:

2-[4-(benzyloxy)benzyl]acetic acid

4-hydroxyphenylacetate

2-(4-benzyloxyphenyl)ethanol

2-(4-benzyloxyphenyl)ethyl β-D-glucopyranoside