Technology Process of 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester,
(2S,4S)-
There total 6 articles about 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester,
(2S,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(benzyloxycarbonyl)-cis-4-carboxy-L-proline dimethyl ester;
With
sodium hydroxide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.5h;
With
hydrogenchloride;
In
water;
pH=3 - 4;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / Reflux
2.1: potassium carbonate / water; diethyl ether / 2 h / 0 - 20 °C
3.1: triethylamine / dichloromethane / 20 - 40 °C
4.1: cesium fluoride / N,N-dimethyl-formamide / 40 h / 60 °C
5.1: 1 h / 0 - 20 °C
5.2: 48 h / 20 °C
6.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 - 20 °C
6.2: pH 3 - 4
With
thionyl chloride; potassium carbonate; triethylamine; cesium fluoride; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / water; diethyl ether / 2 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 20 - 40 °C
3.1: cesium fluoride / N,N-dimethyl-formamide / 40 h / 60 °C
4.1: 1 h / 0 - 20 °C
4.2: 48 h / 20 °C
5.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 - 20 °C
5.2: pH 3 - 4
With
potassium carbonate; triethylamine; cesium fluoride; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
