130830-69-2

Upstream product

• 67-56-1 methanol 
• 130830-65-8 N-(benzyloxycarbonyl)-cis-4-cyano-L-proline ethyl ester 
• 103667-57-8 (2S,4R)-ethyl N¹-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate 
• 130830-60-3 1-benzyl 2-ethyl(2S,4R)-4-[[(4-methylbenzene)sulfonyl]oxy]pyrrolidine-1,2-dicarboxylate 
• 501-53-1 benzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 75-36-5 acetyl chloride 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 

Downstream Products

• 1446653-78-6 (2S,4S)-4-((phenylsulfonyl)methyl)-1-(diphenylacetyl)-pyrrolidine-2-carboxylic acid 
• 1446655-58-8 C₂₇H₂₇NO₅S 
• 1446653-77-5 (2S,4S)-4-((benzylsulfonyl)methyl)-1-(diphenylacetyl)-pyrrolidine-2-carboxylic acid 
• 1446655-56-6 C₂₈H₂₉NO₅S 
• 1446653-66-2 (2S,4S)-1-(2,2-diphenylacetyl)-4-((phenylthio)methyl)pyrrolidine-2-carboxylic acid 
• 1446655-42-0 C₂₇H₂₇NO₃S 
• 1446653-64-0 C₂₇H₂₇NO₃S 
• 1446655-38-4 C₂₈H₂₉NO₃S 
• 1446655-34-0 C₂₉H₃₁NO₃S 
• 1446655-40-8 C₂₂H₂₅NO₆S 
• 1446653-58-2 (2S,4S)-1-(2,2-diphenylacetyl)-4-(5-phenyloxazol-2-yl)pyrrolidine-2-carboxylic acid 
• 1446655-32-8 C₂₉H₂₆N₂O₄ 
• 1446655-30-6 C₁₅H₁₆N₂O₃ 
• 1446655-28-2 C₂₃H₂₂N₂O₅ 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE

The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer

In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.