Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-2-methyl-3-[[(1R) -1-phenylethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester, (2S,3R)-

Base Information

Chemical Name:Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-2-methyl-3-[[(1R) -1-phenylethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester, (2S,3R)-
CAS No.:587840-45-7
Molecular Formula:C39H54N2O4
Molecular Weight:614.869
Hs Code.:

Heptanoic acid,
7-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-2-methyl-3-[[(1R)
-1-phenylethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester, (2S,3R)-

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Chemical Property of Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-2-methyl-3-[[(1R) -1-phenylethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester, (2S,3R)-

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Technology Process of Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-2-methyl-3-[[(1R) -1-phenylethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester, (2S,3R)-

There total 4 articles about Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-2-methyl-3-[[(1R) -1-phenylethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: lithium benzyl-(R)-1-phenylethylamide

: 587840-59-3
7-(benzyl-tert-butoxycarbonyl-amino)-2-methyl-3-(toluene-4-sulfonyloxy)-heptanoic acid tert-butyl ester

: 587840-45-7
(2S,3R)-tert-butyl-7-(benzyl-tert-butoxycarbonylamino)-3-(N-benzyl-N-α-(R)-methylbenzylamino)-2-methylheptanoate

Guidance literature:: 7-(benzyl-tert-butoxycarbonyl-amino)-2-methyl-3-(toluene-4-sulfonyloxy)-heptanoic acid tert-butyl ester; With potassium tert-butylate; In diethyl ether; at -78 ℃; for 2h;

lithium benzyl-(R)-1-phenylethylamide; In toluene;
DOI:10.1021/jo034583h

Reference yield:

: 20487-40-5
tert-butyl propionate

: 587840-45-7
(2S,3R)-tert-butyl-7-(benzyl-tert-butoxycarbonylamino)-3-(N-benzyl-N-α-(R)-methylbenzylamino)-2-methylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: tetrahydrofuran; hexane / 0.25 h

2.1: 16.99 g / DMAP; Et₃N / CH₂Cl₂ / 20 °C

3.1: KOtBu / diethyl ether / 2 h / -78 °C

3.2: 4.64 g / toluene

With dmap; potassium tert-butylate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo034583h

Reference yield:

: 213772-26-0
benzyl-(5-oxo-pentyl)-carbamic acid tert-butyl acid

: 587840-45-7
(2S,3R)-tert-butyl-7-(benzyl-tert-butoxycarbonylamino)-3-(N-benzyl-N-α-(R)-methylbenzylamino)-2-methylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: tetrahydrofuran; hexane / 0.25 h

2.1: 16.99 g / DMAP; Et₃N / CH₂Cl₂ / 20 °C

3.1: KOtBu / diethyl ether / 2 h / -78 °C

3.2: 4.64 g / toluene

With dmap; potassium tert-butylate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo034583h