N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide

Base Information

Chemical Name:N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide
CAS No.:588730-02-3
Molecular Formula:C₁₉H₁₃N₃OS
Molecular Weight:331.398
Hs Code.:
DSSTox Substance ID:DTXSID301235914

Synonyms:N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide;DTXSID301235914;588730-02-3

Suppliers and Price of N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:331.07793322
Heavy Atom Count:24
Complexity:434

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC3=C(N=C2)SC(=N3)NC(=O)C4=CC=CC=C4

Technology Process of N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide

There total 4 articles about N-(6-Phenylthiazolo[5,4-b]pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 588730-01-2
N-(6-bromo-thiazolo[5,4-b]pyridine-2-yl)-benzamide

: 98-80-6
phenylboronic acid

: 588730-02-3
N-(6-phenyl-thiazol[5,4-b]pyridin-2-yl)-benzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1002/jhet.5570400210

Reference yield:

: 98-88-4
benzoyl chloride

: 588730-02-3
N-(6-phenyl-thiazol[5,4-b]pyridin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetone / 0.08 h / Heating

1.2: 100 percent / acetone / 1 h / Heating

2.1: 67 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

3.1: 78 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

4.1: 46 percent / Pd(PPh₃)4; Et₃N / dimethylformamide / 2 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; triethylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetone; 4.1: Suzuki coupling;
DOI:10.1002/jhet.5570400210

Reference yield:

: 588729-97-9
N-(6-bromo[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide

: 588730-02-3
N-(6-phenyl-thiazol[5,4-b]pyridin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

2: 46 percent / Pd(PPh₃)4; Et₃N / dimethylformamide / 2 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; triethylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1002/jhet.5570400210