Pentamethylphosphoramide

Base Information

• Chemical Name: Pentamethylphosphoramide
• CAS No.: 10159-46-3
• Molecular Formula: C5H16 N3 O P
• Molecular Weight: 165.17
• NSC Number: 298104
• DSSTox Substance ID: DTXSID60144035
• Nikkaji Number: J894.156D
• Wikidata: Q83008118
• Mol file: 10159-46-3.mol

Synonyms:ENT 51295;ENT-51295;pentamethylphosphoramide

Chemical Property of Pentamethylphosphoramide

Chemical Property:

• Vapor Pressure: 0.375mmHg at 25°C
• Boiling Point: 197.6°Cat760mmHg
• Flash Point: 73.3°C
• PSA: 45.39000
• Density: 1.041g/cm³
• LogP: 0.82800
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 165.10309914
• Heavy Atom Count: 10
• Complexity: 134

Purity/Quality:

98%,99%, ^*data from raw suppliers

PENTAMETHYLPHOSPHORAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Phosphorus Compounds
• Canonical SMILES: CNP(=O)(N(C)C)N(C)C

Technology Process of Pentamethylphosphoramide

There total 5 articles about Pentamethylphosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N,N',N'-Tetramethylphosphorodiamidic chloride (1605-65-8) + methylamine (74-89-5) → Pentamethylphosphorsaeuretriamid (10159-46-3)

Guidance literature:

at 20 ℃; for 48h;

DOI:10.1016/j.jorganchem.2010.06.020

Reference yield:

N--N-methylformamid (20583-06-6) → Pentamethylphosphorsaeuretriamid (10159-46-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1021/jm00311a602

Reference yield:

N,N,N,N,N,N-hexamethylphosphoric triamide (680-31-9) → Pentamethylphosphorsaeuretriamid (10159-46-3)

Guidance literature:

With potassium permanganate;

DOI:10.1021/jm00311a602

upstream raw materials:

N,N,N',N'-Tetramethylphosphorodiamidic chloride

methylamine

N,N,N,N,N,N-hexamethylphosphoric triamide

N--N-methylformamid

Downstream raw materials:

Hydroxymethylpentamethylphosphorsaeuretriamid

N--N-methylformamid