6H-Pyrido(3,2,1-jk)(1,4)benzodiazepin-4(3H)-one, 7,8-dihydro-1-phenyl-

Base Information

• Chemical Name: 6H-Pyrido(3,2,1-jk)(1,4)benzodiazepin-4(3H)-one, 7,8-dihydro-1-phenyl-
• CAS No.: 28748-77-8
• Molecular Formula: C₁₈H₁₆N₂O
• Molecular Weight: 276.338
• Hs Code.: 2933990090
• Mol file: 28748-77-8.mol

Synonyms:6H-Pyrido(3,2,1-jk)(1,4)benzodiazepin-4(3H)-one, 7,8-dihydro-1-phenyl-

Chemical Property of 6H-Pyrido(3,2,1-jk)(1,4)benzodiazepin-4(3H)-one, 7,8-dihydro-1-phenyl-

Chemical Property:

• Vapor Pressure: 9.53E-12mmHg at 25°C
• Boiling Point: 540.5°Cat760mmHg
• Flash Point: 280.7°C
• PSA: 32.67000
• Density: 1.28g/cm³
• LogP: 2.31740

Purity/Quality:

6H-PYRIDO(3,2,1-JK)(1,4)BENZODIAZEPIN-4(3H)-ONE, 7,8-DIHYDRO-1-PHENYL- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6H-Pyrido(3,2,1-jk)(1,4)benzodiazepin-4(3H)-one, 7,8-dihydro-1-phenyl-

There total 3 articles about 6H-Pyrido(3,2,1-jk)(1,4)benzodiazepin-4(3H)-one, 7,8-dihydro-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4-tetrahydroisoquinoline (635-46-1) → 1-phenyl-7,8-dihydro-3H,6H-[1,4]diazepino[6,7,1-ij]quinolin-4-one (28748-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: BCl₃; AlCl₃ / 1,2-dichloro-ethane

2: pyridine

With pyridine; aluminium trichloride; boron trichloride; In 1,2-dichloro-ethane; 1: Acylation / 2: Cyclocondensation;

DOI:10.1016/S0960-894X(99)00573-9

Reference yield:

benzonitrile (100-47-0) → 1-phenyl-7,8-dihydro-3H,6H-[1,4]diazepino[6,7,1-ij]quinolin-4-one (28748-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: BCl₃; AlCl₃ / 1,2-dichloro-ethane

2: pyridine

With pyridine; aluminium trichloride; boron trichloride; In 1,2-dichloro-ethane; 1: Acylation / 2: Cyclocondensation;

DOI:10.1016/S0960-894X(99)00573-9

Reference yield:

phenyl(1,2,3,4-tetrahydroquinolin-8-yl)methanone (28748-92-7) + methoxycarbonylmethylamine (616-34-2) → 1-phenyl-7,8-dihydro-3H,6H-[1,4]diazepino[6,7,1-ij]quinolin-4-one (28748-77-8)

Guidance literature:

With pyridine;

DOI:10.1016/S0960-894X(99)00573-9

upstream raw materials:

phenyl(1,2,3,4-tetrahydroquinolin-8-yl)methanone

methoxycarbonylmethylamine

1,2,3,4-tetrahydroisoquinoline

benzonitrile

Downstream raw materials:

3-amino-1-phenyl-7,8-dihydro-3H,6H-[1,4]diazepino[6,7,1-ij]quinolin-4-one

1-phenyl-7,8-dihydro-6H-[1,4]diazepino[6,7,1-ij]quinoline-3,4-dione 3-oxime

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